Mural Oncology plc 2024年度报告

Securities registered pursuant to Section 12(b) of the Act: Securities registered pursuant to Section 12(g) of the Act:None Indicate by check mark if the Registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.YES☐NO☒ Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act.YES☐NO☒ Indicate by check mark whether the Registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during thepreceding 12 months (or for such shorter period that the Registrant was required to filesuch reports), and (2) has been subject to such filing requirements for the past 90 days.YES☒NO☐ Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T(§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the Registrant was required to submit such files).YES☒NO☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growthcompany. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act. If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition periodfor complying with any new or revised financial accountingstandards provided pursuant to Section 13(a) of the Exchange Act.☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reportingunder Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report.☐ If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements ofthe registrant included in the filing reflect the correction of anerror to previously issued financial statements.☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).YES☐NO☒ The aggregate market value of the ordinary shares held by non-affiliates of the registrant (without admitting that any person whose shares are not included in such calculation is anaffiliate) computed by reference to the price at which the ordinary shareswere last sold as of the last business day of the registrant’s most recently completed second fiscal quarter was$32,178,017. As of February 28, 2025, the registrant had 17,228,291 ordinary shares outstanding. DOCUMENTS INCORPORATED BY REFERENCE The registrant intends to file a definitive proxy statement pursuant to Regulation 14A relating to the 2024 Annual General Meeting of Shareholders within 120 days of the end of theregistrant’s fiscal year ended December31, 2024. Portions of such definitive proxy statement are incorporated by reference into Part III of this Annual Report on Form 10-K to the extent statedherein. Table of Contents Cautionary Statement Regarding Forward-Looking Statements1Summary of the Material Risks Associated With Our Business2 PART IItem 1.Business Item 1A.Risk FactorsItem 1B.Unresolved Staff CommentsItem 1C.CybersecurityItem 2.PropertiesItem 3.Legal ProceedingsItem 4.Mine Safety Disclosures PART IIItem 5.Market for Registrant’s Common Equity,Related Stockholder Matters and Issuer Purchases of Equity Securities 106 Item 6.[Reserved]106Item 7.Management’s Discussion and Analysis of Financial Condition and Results ofOperations107Item 7A.Quantitative and Qualitative Disclosures About Market Risk118Item 8.Financial Statements and Supplementary Data118Item 9.Changes in and Disagreements With Accountants on Accounting and Financial Disclosure142Item 9A.Controls and Procedures142Item 9B.Other Information143Item 9C.Disclosure Regarding Foreign Jurisdictions that Prevent Inspections143 PART IIIItem 10.Directors, Executive Officers and Corporate Governance 144Item 11.Executive Compensation144Item 12.Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters144Item 13.Certain Relationships and RelatedTransactions, and Director Independence144Item 14.Principal Accounting Fees and Services144 PART IVItem 15.Exhibits and Financial StatementSchedules 145Item 16.Form 10-K Summary147 CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS ThisAnnual Report on Form 10-K includes forward-looking statements within the meaning of the U.S. Private SecuritiesLitigation Reform Act and Section 21E of the Securities Exchange Act of 1934, as amended, that involve substantial risks anduncertainties. Allstatements contained in this Annual Report, other than statements of historical facts, including statements abo