uniQure NV 2024年度报告

The Nasdaq Stock Market LLC (The Nasdaq Global Select Market) Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.Yes☒No☐ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.Yes☐No☒ Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during thepreceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90days.YesNo Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of RegulationS-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).Yes☒No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerginggrowth company. See the definitions of “large accelerated filer”, “accelerated filer”, “smaller reporting company” and “emerging growth company” in Rule 12b-2 of theExchange Act. Large accelerated filer☐Accelerated filer☒Non-accelerated filer☐Smaller reporting company☐Emerging growth company☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revisedfinancial accounting standards provided pursuant to Section 13(a) of the Exchange Act.☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control overfinancial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report.☒ If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflectthe correction of an error to previously issued financial statements.☐ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by anyof the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b).☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act.)Yes☐No The aggregate market value of the voting and non-voting ordinary shares held by non-affiliates of the registrant, computed by reference to the closing price on theNasdaq Global Select Market as of the last business day of the registrant’s most recently completed second fiscal quarter, was approximately $218.15 million. As of February 24, 2025, the registrant had 54,076,880 ordinary shares, par value €0.05, outstanding. DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant’s definitive Proxy Statement for its 2025 Annual Meeting of Shareholders to be filed with the Securities and Exchange Commission nolater than April 30, 2025 and are herein incorporated by reference in Part III of this Annual Report on Form 10-K. TABLE OF CONTENTS PART ISPECIAL CAUTIONARY NOTICE REGARDING FORWARD-LOOKING STATEMENTS3Item 1Business6Item 1ARisk Factors40Item 1BUnresolved Staff Comments83Item 1CCybersecurity83Item 2Properties84Item 3Legal Proceedings84Item 4Mine Safety Disclosures84PART IIItem 5Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases ofEquity Securities85Item 6Reserved86Item 7Management’s Discussion and Analysis of Financial Condition and Results of Operations87Item 7AQuantitative and Qualitative Disclosures About Market Risk106Item 8Financial Statements and Supplementary Data108Item 9Changes in and Disagreements With Accountants on Accounting and Financial Disclosure108Item 9AControls and Procedures108Item 9BOther Information109Item 9CDisclosure Regarding Foreign Jurisdictions that Prevent Inspections110PART IIIItem 10Directors, Executive Officers and Corporate Governance110Item 11Executive Compensation110Item 12Security Ownership of Certain Beneficial Owners and Management and Related StockholderMatters110Item 13Certain Relationships and Related Transactions, and Director Independence110Item 14Principal Accounting Fees and Services110PART IVItem 15Exhibits, Financial Statement Schedules111Item 16Form 10-K Summary111 SPECIAL CAUTIONARY NOTICE REGARDING FORWARD-LOOKING STATEMENTS This Annual Report on Form 10-K contains “forward-looking statements” as defined under federal securitieslaws. Forward-looking statements are based on our current expectations of future events and many of these statements canbe identified using terminology such as “believes,” “exp