德纳维制药 2024年度报告

SECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549________________________________________________________ Form 10-K (Mark One) Dynavax Technologies Corporation (Exact name of registrant as specified in its charter)________________________________________________________ (IRS EmployerIdentification No.) 2100 Powell Street, Suite 720Emeryville, CA 94608(510) 848-5100 (Address, including Zip Code, and telephone number, including area code, of the registrant’s principal executive offices)________________________________________________________ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 ofRegulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registration was required to submit suchfiles).Yesx NooIndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer”, “smaller reporting company” and “emerging growthcompany” in Rule 12b-2 of the Exchange Act. If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any newor revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.oIndicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm thatprepared or issued its audit report.x If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in thefiling reflect the correction of an error to previously issued financial statements.o Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation receivedby any of the registrant’s executive officers during the relevant recovery period pursuant to § 240.10D-1(b).o Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).Yeso NoxThe aggregate market value of the voting and non-voting stock held by non-affiliates of the registrant, based upon the closing sale price of the common stock on June 30, 2024 as reported on the Nasdaq Global Select Market, was approximately $0.8 billion. Shares of common stock held by each officer anddirector and by each person known to the Company who owns 5% or more of the outstanding common stock have been excluded in that such persons maybe deemed to be affiliates. This determination of affiliate status is not necessarily a conclusive determination for other purposes. As of February 18, 2025, the registrant had outstanding 124,070,829shares of common stock. DOCUMENTS INCORPORATED BY REFERENCE Portions of the Definitive Proxy Statement for the registrant’s 2025 Annual Meeting of Stockholders are incorporated by referenceinto Part III, Items 10-14 of this Form 10-K. The Definitive Proxy Statement will be filed no later than 120 days after the close of the registrant’s fiscalyear ended December 31, 2024. Auditor Firm Id:42 INDEX DYNAVAX TECHNOLOGIES CORPORATION PART I Item 1.BUSINESS6Item 1A.RISK FACTORS25Item 1B.UNRESOLVED STAFF COMMENTS55Item 1C.CYBERSECURITY55Item 2.PROPERTIES57Item 3.LEGAL PROCEEDINGS57Item 4.MINE SAFETY DISCLOSURE57PART IIItem 5.MARKET FOR THE REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDERMATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES58Item 6.[RESERVED]59Item 7.MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION ANDRESULTS OF OPERATIONS60Item 7A.QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK71Item 8.FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA72Item 9.CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTINGAND FINANCIAL DISCLOSURE107Item 9A.CONTROLS AND PROCEDURES107Item 9B.OTHER INFORMATION109Item 9C.DISCLOSURE REGARDING FOREIGN JURISDICTIONS THAT PREVENTINSPECTIONS110PART IIIItem 10.DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE111Item 11.EXECUTIVE COMPENSATION111Item 12.SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENTAND RELATED STOCKHOLDER MATTERS111Item 13.CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTORINDEPENDENCE111Item 14.PRINCIPAL ACCOUNTANT FEES AND SERVICES111PART IVItem 15.EXHIBIT AND FINANCIAL STATEMENT SCHEDULES112Item 16.FORM 10-K SUMMARY119SIGNATURES120 FORWARD-LOOKING STATEMENTS This Annual Report on Form 10-K contains forward-looking statements within the meaning ofSection 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, asamended, which are subject to a numbe