Harmony Biosciences Holdings Inc 2024年度报告

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes䖶No䖴 Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes䖴No䖶 Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes䖶No䖴 Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 ofthis chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes䖶No䖴 Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growthcompany. See definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act: Large accelerated filer䖶Accelerated filerտNon-accelerated filer䖴Smaller reporting companyտEmerging growth companyտ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financialaccounting standards provided pursuant to Section 13(a) of the Exchange Act.տ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reportingunder Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report.䖶 If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction ofan error to previously issued financial statements.տ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of theregistrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b).տ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). YesտNo䖶 The aggregate market value of the voting and non-voting stock held by non-affiliates of the Registrant, as of June 28, 2024, the last business day of the registrant’s most recentlycompleted second fiscal quarter, was $903.8 million. As of February 21, 2025, the registrant had 57,345,611 shares of common stock, $0.00001 par value per share, outstanding. DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant’s definitive proxy statement relating to its 2025 Annual Meeting of Stockholders to be filed with the Securities andExchange Commission within 120 days after the end of the fiscal year ended December 31, 2024, are incorporated herein by reference in Part III whereindicated. TABLE OF CONTENTS PagePart I3CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS3ITEM 1. BUSINESS.5ITEM 1A. RISK FACTORS.26ITEM 1B. UNRESOLVED STAFF COMMENTS.71ITEM 1C. CYBERSECURITY71ITEM 2. PROPERTIES.74ITEM 3. LEGAL PROCEEDINGS.74ITEM 4. MINE SAFETY DISCLOSURES.74Part II75ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDERMATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES.75ITEM 6: [RESERVED]76ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION ANDRESULTS OF OPERATIONS.76ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.88ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.88ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING ANDFINANCIAL DISCLOSURE.117ITEM 9A. CONTROLS AND PROCEDURES.117ITEM 9B. OTHER INFORMATION.119ITEM 9C. DISCLOSURES REGARDING FOREIGN JURISDICTIONS THAT PREVENTINSPECTIONS119Part III120ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE.120ITEM 11. EXECUTIVE COMPENSATION.120ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENTAND RELATED STOCKHOLDER MATTERS.120ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTORINDEPENDENCE.120ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES.120Part IV121ITEM 15. EXHIBITS, FINANCIAL STATEMENT SCHEDULES.121ITEM 16. FORM 10-K SUMMARY.124SIGNATURES124 Part I Cautionary Note Regarding Forward-Looking Statements This Annual Report on Form 10-K contains forward-looking statements. We intend such forward-looking statementsto be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Actof 1933, as amended (the “Securities Act”), and Section 21E of t