Ultragenyx Pharmaceutical Inc 2024年度报告

Washington, D.C. 20549 Form 10-K Securities registered pursuant to Section 12(b) of the Exchange Act: Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Exchange Act.YESտNOր Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the preceding 12months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.YESրNOտ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 ofRegulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).YesրNOտ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or anemerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule12b-2 of the Exchange Act. Accelerated filerտNon-accelerated filerտSmaller reporting companyտEmerging growth companyտ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal controlover financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its auditreport.րIf securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements ofthe registrant included in the filing reflect the correction of an error to previously issued financial statements.տ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation receivedďLJĂŶLJŽĨƚŚĞƌĞŐŝƐƚƌĂŶƚ͛ƐĞdžĞĐƵƚŝǀĞŽĸĐĞƌƐĚƵƌŝŶŐƚŚĞƌĞůĞǀĂŶƚƌĞĐŽǀĞƌLJƉĞƌŝŽĚƉƵƌƐƵĂŶƚƚŽΑϮϰϬ͘ϭϬ-1(b).տ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).YESտNOր The aggregate market value of the voting and non-voting common equity held by non-affiliates of the Company as of June 30, 2024 was approximately $3.7billion, based upon the closing price on The Nasdaq Global Select Market reported for such date. Shares of common stock held by each executive officer and directorand by each person who is known to own 10% or more of the outstanding common stock have been excluded as such persons may bedeemed affiliates of theCompany. This determination of affiliate statusis not necessarily a conclusive determination for other purposes. As of February 13, 2025, the Company had92,501,126 shares of common stock issued and outstanding. DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant’s definitive proxy statement relating to its 2025 Annual Meeting of Stockholders, to be held on orabout May 15, 2025, areincorporated by reference into Part III of this Annual Report on Form 10-K where indicated. Such proxy statement will be filed with the U.S. Securities and ExchangeCommission within 120 days after the end of the fiscal year to which this report relates. Table of Contents PART IItem 1.Business4Item 1A.Risk Factors29Item 1B.Unresolved Staff Comments67Item 1C.Cybersecurity67Item 2.Properties67Item 3.Legal Proceedings68Item 4.Mine Safety Disclosures68PART IIItem 5.Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities69Item 6.Reserved70Item 7.Management’s Discussion and Analysis of Financial Condition and Results of Operations71Item 7A.Quantitative and Qualitative Disclosures About Market Risk81Item 8.Financial Statements and Supplementary Data82Item 9.Changes in and Disagreements With Accountants on Accounting and Financial Disclosure82Item 9A.Controls and Procedures82Item 9B.Other Information84Item 9C.Disclosure Regarding Foreign Jurisdictions that Prevent Inspections85PART IIIItem 10.Directors, Executive Officers and Corporate Governance86Item 11.Executive Compensation86Item 12.Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters86Item 13.Certain Relationships and Related Transactions, and Director Independence86Item 14.Principal Accountant Fees and Services86PART IVItem 15.Exhibits and Financial Statement Schedules87Item 16.Form 10-K Summary92SIGNATURES93 CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS This Annual Report on Form 10-K, or Annual Report, contains forward-looking statements that involve risks and uncertainties.We make such forward-looking statements pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of1995 and other federal securities laws. All statements other t