方达控股：全年业绩公告截至2024年12月31日止年度

(1) (2) 2023 20241231 20241231 1. 20184162019530 Cricket Square, Hutchins Drive,P.O. Box 2681, Grand Cayman, KY1-1111 Cayman Islands700 Pennsylvania Drive, Exton, PA 19341, USA33191920 2. 202411 202411 1 1677 3. 4. ADMEDMPKAPI 2023 (i)(ii)(iii) 15(i)(ii) 5. 8 20242023123110% 6. 7. 8. 9. 10. 2024123124.66%202325.77%20172017122220172024123120231231 BRI Biopharmaceutical Research, Inc.BRICCPC27% Nucro-Technics, Inc.NucroCCPC26.5% 25% 202011202311202315% 2021112021202315% 202212202215% 70%202012202310202315% 20242023123116.5%20183212017720183282,000,0008.25%2,000,00016.5%201841 2024123120231231 11. (i) 3090 909118018111 13. 14. 202412310.02%4.33%20230.02%4.2% 300,0002027 20241231382,0002023369,00020241231382,0002023369,000 2024123126,0004,0002023208,00029,000 3090 16. 17. 510,000,00070,948,0002023517,000,00072,995,000177,344,00024,670,0002023177,327,00025,036,00020241231 2022531Frontage LabsFrontageLabs54,000,0002024123135,000,00020239,000,000Frontage Labs 2022722Frontage LabsFrontage Labs49,000,0002024123136,000,000202347,400,000Frontage LabsFrontageLabs 2 0 2 41 23 13 0 4 , 4 3 6 , 0 0 042,351,0002023335,780,00047,408,00019,000,000202336,000,000 18. 2023112023123120241120241231 202311(a) 20231231202411(a)(b) (a)2024123136,179,00020236,934,5002,312,0002023444,0009,530,00020231,785,000 (b)2024123163,100,00015,122,0001,00015,121,000 19. (IND)(FIH) 2024AcceleraS.r.l.AcceleraAcceleraNMS Group S.p.A.Accelera 202446,300 202420 2024 20231231259.91.9%20241231254.920241231390.620231231342.214.1% 202435%1 ADME/PK(ADC)50%PK PK202414C(hAME)(QWBA) hERGGLPAAALAC 46,3004°C-70°C-80°CPBMCDNAFFPE200,000 AcceleraAccelera 23 2024 (NMPA)2024 11810,000API 2024GLP89,000 PRMT5T2(AhR)NMPAINDUSP1APIFDA ADCp-Tau217(LDT)(Journal ofPrevention of Alzheimer’s Disease)LDT(RWE) (BE)(FDA)BE 20241231(13) •(3)•(2)•(1)•(1)•(1)•(1)•(1)•(1)•(1)•(1) 20241231(11) •(4)•(4)•(1)•(2) SOPSOP F D AD E ACNSCPHAC( C L I A / C A P )D O HAAALACUSDA NMPA Frontage LabsZenQMSSOPKPI (SDWAN)SDWANSDWANGDPRISO 27001NetSuiteSalesforce SOPUSDAFDA Frontage LabsPharma Tech Outlook202420 2023616Frontage LabsAcceleraNMS Group S.p.A.Frontage LabsFrontage Europe S.r.l.Frontage EuropeAccelera6,835,000 202411Accelera 20241231 20241231 IIV2024834.920321,926.820242032(CAGR)11.1%2 2https://www.businessresearchinsights.com/market-reports/contract-research-organization-cro-market-117896 (AI) 20 20231231259.91.9%20241231254.9 20231231199.10.5%20241231198.220231231428.960.85.9%20241231403.556.7 2023123143.013.5%2024123137.22024123114.6%2023123116.5% 2023123159.912.4%2024123152.52024123120.6%2023123123.0% 20231231181.52.0%20241231185.1NucroFrontage Europe2023820241NucroFrontage Europe 2023123178.411.0%2024123169.82023123130.2%2024123127.4%2023123133.2%2024123129.3%2023123120.4%2024123120.7% 202312314.810.4%202412314.3 202312311.1202412310.2 202312318.23.7%202412318.5 2023123144.65.6%2024123147.12023123133.74.2%2024123135.1NucroFrontage Europe2023820241 (i)(ii) 202312316.06.7%202412315.6 202312317.135.2%202412319.6 202312313.844.7%202412312.1 202412310.62023123110.7202412310.2%202312314.1%20231231 2023123124.045.0%2024123113.2202412315.2%202312319.2%20241231 32023123157.212.6%2024123150.02024123119.6%2023123122.0%NucroFrontage Europe 42023123163.214.6%2024123154.02023123124.3%2024123121.2% 202312310.0053202412310.0004202312310.0052202412310.0004 202412310.0066202312310.011844.1%202412310.0066202312310.0116 3(i)(ii)(iii) 4 2024123154.32023123159.18.1% 2024123130.02023123137.219.4% 2023123161.312.7%2024123169.1 2023123138.750.1%2024123119.3Quintara 9.4% 2024123144.12023123153.2 2024123125.92023123121.222.2% 2024123195.72023123181.4202412312.75%6.73%71.0177.324.7 2024123158.72023123163.7 20241231 100%202412312023123133.0%26.2% 202412311,5608397211,29126984%562 20241231114.620231231112.2 20182021 2023 2025528 2025523202552820255221617 2024123150,788,00087,109,21047,252,0002024415 2024 2024123120241231 2 20242024 (www.hkexnews.hk)(www.frontagelab.com) QuintaraDiscovery,Inc.2013517Frontage LabsWentao ZhangQiulei RenXiang Wu42%26%32% * 2025327 Yin Zhuan *