Alumis Inc 2024年度报告

FORM10-K ☒ANNUAL REPORT PURSUANT TO SECTION13 OR 15(d)OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscalyear endedDecember31, 2024OR☐TRANSITION REPORT PURSUANT TO SECTION13 OR 15(d)OF THE SECURITIES EXCHANGE ACT OF 1934For the transition period fromtoCommission file number:001-42143AlumisInc.(Exact name of registrant as specified in its charter) 280 East Grand AvenueSouth San Francisco,CA94080(Address of Principal Executive Offices)(650)231-6625(Registrant’s telephone number) Securities registered pursuant to Section12(b)of the Act: Name Of Each Exchange Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule405 of the Securities Act.Yes☐No☒ Indicate by check mark if the registrant is not required to file reports pursuant to Section13 or Section15(d)of the Act.Yes☐No☒ Indicate by check mark whether the registrant: (1)has filed all reports required to be filed by Section13 or 15(d)of the Securities Exchange Act of 1934 duringthe preceding 12months (or for such shorter period that the registrant was required to file such reports), and (2)has been subject to such filing requirements forthe past 90days.Yes☒No☐ Indicate by check mark whether the Registrant has submitted electronically; every Interactive Data File required to be submitted pursuant to Rule405 ofRegulation S-T (§232.0405 of this chapter) during the preceding 12months (or for such shorter period that the registrant was required to submit such files).Yes☒No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerginggrowth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule12b-2of the Exchange Act. Large accelerated filer☐Accelerated filer☐Non-accelerated filer☒Smaller reporting company☒Emerging growth company☒ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new orrevised financial accounting standards provided pursuant to Section13(a)of the Exchange Act.☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control overfinancial reporting under Section404(b)of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its auditreport.☐ If securities are registered pursuant to Section12(b)of the Act, indicate by check mark whether the financial statements of the registrant included in the filingreflect the correction of an error to previously issued financial statements.☐ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by anyof the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b).☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule12b-2 of the Exchange Act). Yes☐No☒ Based on the closing price as reported on the Nasdaq Global Select Market, the aggregate market value of the registrant’s voting and non-voting common stockheld by non-affiliates on June 30, 2024 (the last business day of the registrant’s most recently completed second fiscal quarter) plus the aggregate amount of grossproceeds received from the registrant’s initial public offering from non-affiliates was approximately $165.4million. Shares of common stock held by eachexecutive officer and director and by each stockholder affiliated with a director or an executive officer have been excluded from this calculation because suchpersons may be deemed to be affiliates. This determination of affiliate status is not necessarily a conclusive determination for other purposes. As of March 12,2025, the registrant had47,222,419shares of voting common stock, $0.0001 par value per share, and7,184,908shares of non-voting common stock, $0.0001 parvalue per share, outstanding. Documents Incorporated by Reference Certain information required by Part III, Items 10-14 of this Form10-K is incorporated by reference to the registrant’s definitive Proxy Statement for the 2025Annual Meeting of Stockholders to be filed with the Securities and Exchange Commission pursuant to Regulation 14A. If such Proxy Statement is not filed within120 days after the end of the fiscal year covered by this Form10-K, such information will be included in an amendment to this Form10-K to be filed within such120-day period. TABLE OF CONTENTS PagePART IItem1. Business7Item1A. Risk Factors33Item1B. Unresolved Staff Comments99Item 1C. Cybersecurity99Item2. Properties100Item3. Legal Proceedings100Item4. Mine Safety Disclosures100PART IIItem5. Market for the Registrant’s Common Equity, Related Stockholder Matters and IssuerPurchases of Equity Securities101Item6