Design Therapeutics Inc 2024年度报告

Indicate by check mark if the Registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes☐No☐ Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes☐No☐ Indicate by check mark whether the Registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities ExchangeAct of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has beensubject to such filing requirements for the past 90 days. Yes☐No☐ Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant toRule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the Registrant wasrequired to submit such files). Yes☐No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reportingcompany, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,”and “emerging growth company” in Rule 12b-2 of the Exchange Act. If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complyingwith any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of itsinternal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered publicaccounting firm that prepared or issued its audit report.☐ If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrantincluded in the filing reflect the correction of an error to previously issued financial statements.☐ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-basedcompensation received by any of the registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b).☐ Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes☐No☐ The aggregate market value of the Common Stock held by non-affiliates of the Registrant, based on the closing price of the shares of commonstock on The Nasdaq Global Select Market on June 28, 2024, the last business day of the Registrant's most recently completed second quarter,was approximately $112,536,269.The number of shares of Registrant’s Common Stock outstanding as of March 6, 2025 was 56,762,678.DOCUMENTS INCORPORATED BY REFERENCEPortions of the registrant's definitive proxy statement for its 2025 Annual Meeting of Stockholders, which the registrant intends to filepursuant to Regulation 14A with the Securities and Exchange Commission no later than April 30, 2025, are incorporated by reference intoPart III of this Annual Report on Form 10-K. Table of Contents PART IItem 1.Business6Item1A.Risk Factors54Item1B.Unresolved Staff Comments111Item1C.Cybersecurity111Item 2.Properties112Item 3.Legal Proceedings112Item 4.Mine Safety Disclosures112 PARTII Item 5.Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases ofEquity Securities113Item 6.[Reserved]113Item 7.Management’s Discussion and Analysis of Financial Condition and Results of Operations114Item7A.Quantitative and Qualitative Disclosures About Market Risk123Item 8.Financial Statements and Supplementary Data124Item 9.Changes in and Disagreements with Accountants on Accounting and Financial Disclosure147Item9A.Controls and Procedures147Item9B.Other Information147Item9C.Disclosure Regarding Foreign Jurisdictions that Prevent Inspections147 PARTIIIItem10.Directors, Executive Officers and Corporate Governance148ItemExecutive Compensation148 11.Item12.Security Ownership of Certain Beneficial Owners and Management and Related StockholderMatters148Item13.Certain Relationships and Related Transactions, and Director Independence148Item14.Principal Accounting Fees and Services148 PARTIVItem15.Exhibits, Financial Statement SchedulesItem16.Form 10-K Summary 149 150 PART I Special Note Regarding Forward-Looking Statements This Annual Report on Form 10-K and the information incorporated herein by reference contain forward-lookingstatements that involve risks and uncertainties. We make such forward-looking statements pursuant to the safeharbor provisions of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. Allstatements other than statements of historical facts contained in this Annual Report are forward-lookingstatements. In some cases, you can ide