Design Therapeutics Inc 2024年度报告

Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes☐No☒ Indicate by check mark whether the Registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during thepreceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for thepast 90 days.Yes☒No☐ Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of RegulationS-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the Registrant was required to submit such files).Yes☒No☐Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2of the Exchange Act. Large accelerated filer☐Non-accelerated filer☒Emerging growth company☒ Accelerated filer☐Smaller reporting company☒ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revisedfinancial accounting standards provided pursuant to Section 13(a) of the Exchange Act.☒ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control overfinancial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its auditreport.☐ If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflectthe correction of an error to previously issued financial statements.☐ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any ofthe registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b).☐ The aggregate market value of the Common Stock held by non-affiliates of the Registrant, based on the closing price of the shares of common stock on The NasdaqGlobal Select Market on June 28, 2024, the last business day of the Registrant's most recently completed second quarter, was approximately$112,536,269.The number of shares of Registrant’s Common Stock outstanding as of March 6, 2025 was56,762,678. DOCUMENTS INCORPORATED BY REFERENCEPortions of the registrant's definitive proxy statement for its 2025 Annual Meeting of Stockholders, which the registrant intends to file pursuant to Regulation 14A with the Securities and Exchange Commission no later than April 30, 2025, are incorporated by reference into Part III of this Annual Report on Form 10-K. Table of Contents PART I Item 1.BusinessItem 1A.Risk FactorsItem 1B.Unresolved Staff CommentsItem 1C.CybersecurityItem 2.PropertiesItem 3.Legal ProceedingsItem 4.Mine Safety Disclosures PART II Item 5.Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of EquitySecurities113Item 6.[Reserved]113Item 7.Management’s Discussion and Analysis of Financial Condition and Results of Operations114Item 7A.Quantitative and Qualitative Disclosures About Market Risk123Item 8.Financial Statements and Supplementary Data124Item 9.Changes in and Disagreements with Accountants on Accounting and Financial Disclosure147Item 9A.Controls and Procedures147Item 9B.Other Information147Item 9C.Disclosure Regarding Foreign Jurisdictions that Prevent Inspections147 PART III Item 10.Directors, Executive Officers and Corporate Governance148Item 11.Executive Compensation148Item 12.Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters148Item 13.Certain Relationships and Related Transactions, and Director Independence148Item 14.Principal Accounting Fees and Services148 PART IV Item 15.Exhibits, Financial Statement Schedules149Item 16.Form 10-K Summary150 PART I Special Note Regarding Forward-Looking Statements This Annual Report on Form 10-K and the information incorporated herein by reference contain forward-looking statementsthat involve risks and uncertainties. We make such forward-looking statements pursuant to the safe harbor provisions of the PrivateSecurities Litigation Reform Act of 1995 and other federal securities laws. All statements other than statements of historical factscontained in this Annual Report are forward-looking statements. In some cases, you can identify forward-looking statements bywords such as “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect