阿尔凯默斯 2024年度报告

(Mark One)☐ ALKERMES PUBLIC LIMITED COMPANY Name of each exchange on which registered Securities registered pursuant to Section 12(g) of the Act: None Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes☐No☐Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Exchange Act.Yes☐No☐ Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the SecuritiesExchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports),and (2) has been subject to such filing requirements for the past 90 days. Yes☐No☐ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submittedpursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period thatthe registrant was required to submit such files). Yes☐No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smallerreporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smallerreporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act. Large Accelerated Filer☐Non-Accelerated Filer☐ Accelerated Filer☐Smaller Reporting Company☐Emerging Growth Company☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period forcomplying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.☐Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of theeffectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) bythe registered public accounting firm that prepared or issued its audit report.☐If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of theregistrant included in the filing reflect the correction of an error to previously issued financial statements.☐Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-basedcompensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b).☐Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes☐No☐The aggregate market value of the registrant’s ordinary shares held by non-affiliates of the registrant (without admitting that anyperson whose shares are not included in such calculation is an affiliate) computed by reference to the price at which the ordinaryshares were last sold as of the last business day of the registrant’s most recently completed second fiscal quarter was $3,943,314,276.As of February 7, 2025, 162,614,067 ordinary shares were outstanding. DOCUMENTS INCORPORATED BY REFERENCE Portions of the definitive proxy statement for our 2025 Annual General Meeting of Shareholders are incorporated by reference into ALKERMES PLC ANDSUBSIDIARIESANNUAL REPORT ON FORM 10-KFOR THE YEAR ENDED DECEMBER 31, 2024INDEX PART IItem 1.Business6Item 1A.Risk Factors30Item 1B.Unresolved Staff Comments51Item 1C.Cybersecurity51Item 2.Properties52Item 3.Legal Proceedings52Item 4.Mine Safety Disclosures52PART IIItem 5.Market for Registrant’s Common Equity, Related Stockholder Matters and IssuerPurchases of Equity Securities53Item 6.[Reserved]55Item 7.Management’s Discussion and Analysis of Financial Condition and Results ofOperations56Item 7A.Quantitative and Qualitative Disclosures about Market Risk66Item 8.Financial Statements and Supplementary Data67Item 9.Changes in and Disagreements with Accountants on Accounting and FinancialDisclosures68Item 9A.Controls and Procedures68Item 9B.Other Information69Item 9C.Disclosure Regarding Foreign Jurisdictions that Prevent Inspections69PART IIIItem 10.Directors, Executive Officers and Corporate Governance70 Item 11.Executive Compensation70Item 12.Security Ownership of Certain Beneficial Owners and Management and RelatedStockholder Matters70Item 13.Certain Relationships and Related Transactions, and Director Independence70Item 14.Principal Accounting Fees and Services70PART IVItem 15.Exhibits and Financial Statement Schedules71Item 16.Form 10-K Summary77SIGNATURES78 CAUTIONARY NOTE CONCERNING FORWARD-LOOKING STATEMENTS This document contains and incorporates by reference “forward-looking statements” within the meaning ofSection 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the SecuritiesExchange Act of 1934, as amended (the “E