234516224275102104109110112113115179 33191901 20236 2620236 26 97927 20236 2620236 26 8126 20236 26 501911 12 20236 26 H 183171712-1716 1-38 20238 3120238 31 2185 www.bio-heart.com 202112 23 59043 302 202312 31 (i)(BRS)(ii)(RDN) 2023Bioheart®Iberis HTNRDNRDNIberis®62023Iberis HTN10BRSRDN RDNIberis®(TRI)RDN20TRI RDNTRAIberis®PMDA RDN202311FDATRI RDN I. (i) BRS(ii) RDN BRS Bioheart®BRSPCIBRS40Bioheart®2017220222 16Bioheart®2024 RDN Iberis®RDNRDNIberis®20Iberis®20161120221 26Iberis®20234 11Iberis®Iberis-HTN20232024 (European Cardiovascular Research Center)Iberis®RDNRADIUS-HTNRADIUS-HTNTRATFACETRATFATRATFATRAIberis®20233 27RADIUS-HTN(CentreHospitalier Universitaire de Bordeaux) DCBDEBDCB90 DCB DCBBRSPMDA RDN •RDNDCB •8040 •CERDN 20234 1415,000,000361,14414,638,85622.18%DCB20235DCBDCBDCBBRSDCB20234 14 •Bioheart®Iberis®BRSRDN••••• II. 2023202212 31188.8230.9 202223.820238.616.9 (i)(ii)(iii)(iv)2022202367.422.2 202294.4202352.9145.223.837.12023 (i)(ii)(iii)(iv) 2022202373.125.4 2022157.82023111.7 20220.1202330.6 20221.020230.6 25% 16.5% 20232022188.8230.9 202312 3149.0 202312 3128.917.715.0 202312 315.8 202312 31369.4202212 31451.318.1% 202212 31512.7202312 31388.4 202230.0202317.7 202312 31 202212 3118.1202312 311.8 202312 31100%5.4%202212316.8% 202312 3120227.6 202312 31 202312 31 202312 3132(i)(ii)(iii)(iv)65.2 2020914,509,4132020202020201.0 20226 272022H202220222022202229 202112 23441.69 1.202312 31 2. 20242 20231 13100,107,42574,509,781H20231 13 20242 820242 8247.10 (i)RDNIberis®26.3720243 (ii)Bioheart®70DCB 20242 8 55201412 8202011 24 2011920214 252002201208532013420194300326201320201220209 34%62.19% 1993619966 3920209 4202011 24202011 24202012 9 2006920111220111220151020151020209 5.0%8.10% 200662019820124 40202211 10202211 1020147 1201191020049200562005720065200662010720108201312 1.62%3.5% 2009120105 704019771988199420027201261998 201922019620211189636926808202212002352201652019560302013920204Changyou.com20204201272022101207 19775 44 201252016600241820148202083003262020620209 20226300326 2003620082 5319945(Georgetown University)1995119966(Barclaysde Zoete Wedd)1996619983(J.P. Morgan)1998619999SociétéGénérale1999920021Deutsche Bank20022(Longitude Asia Limited)20026 39202012 820147 201132012320123201332013420147 2008720114 3.0%7.56% 37202211 10202091.5% 2009820209 2009620131220191220146 3520167 2720238 310.5% 2011620121201232013320133201660853 20116GlyndwrUniversityMBA 5520147 18 39202011 24 3920147 18 4120147 1 Bradley Stewart HUBBARD6620213 1 19947200110Guidant Corporation200110200912Surpass-Silicon Valley, LLCLyChron, LLC2009120181201852019220212 Hubbard198012198451984620036 39202012 9 40202012920147Vistra CorporateServices (HK) LimitedVistra Corporate Services (HK) Limited 201262017112018 222266092373 13.51B(1) 202312 31 2023 ••• C.2.12 2C.2.12C.2.1 12 34 1.20236 262.20236 263.20236 26202312 313.09D20236 264.20236 26 1621 3.13 3.21A.2D.33.10(2)3.21 (i)(ii)(iii)(iv)(v) ••• 3.25E.1 (i)(ii)(iii)(iv)(v) E.1.2(c)(ii) •••• 9 3.27B.3 (i)(ii)(iii)(iv)(v) • •• 13.92 31404150516060 20% 202312 3118:14 (i)(ii)(iii) • • •(i)(ii)(iii) • (i)(ii)(iii) (i)(ii)(iii)(iv)(v)(vi) •••• •••• •••••• 202312 31 (i)(ii) A.2.1 •••• C.5.1 1.20236 262.20236 263.20236 264.20236 26 20236 26 104108 1.520230.5 Vistra Corporate Services (HK) Limited 3.2915 879010% 593%10683% 102(7) 5904 3 302info@bio-heart.com (i)(ii)(iii)(iv)(v)H(vi) 20236 26123,390,910115,677,232H7,713,67850.58% 2023 10%50%(i)(ii) 20236 26 (i)(BRS)(ii)(RDN) 1. 2. (www.bio-heart.com) 20231 1202312 31 KPI20231 1202312 312022 C2 KPIKPI 2022 20243 25 info@bio-heart.com •••• •••• 3 324 A. GHG A1. A1.1. 2023 A1.2. 635.722022818.53(tCO2e)GHG 19.87202215.16 0.2420220.187.5620223.33 A1.4. 0.7020221.00 2023 0.0220220.02 A1.5. •••••• •••LED••• A1.6. 1% A2. A2.1. 968.6020221,309.531906.836,970.0061,769.12 2023 A2.2. 1,577.0020222,217.3749.28202241.06 A2.3. 1% A2.4. • • • 1% A2.5. 110.00 A3. A3.1. 1% A4. B. B1. B1.1. 202312 3132202254 B1.2. 4720224146.88%20227.41% B1.3. B1.4. B1.5. B.2. 2023 B.3. 234.38%6.97 •••••SOP B4. 16 C. C1. ISO13485 ISO14001 147202214213820221257202215220222ACAISO13485 C2. C2.1 GMPISO 134852016 202320222022 C2.2 C2.3 202312 3180202279252022254120225315202215 •••• C2.4 C2.5 C3. D. (i)(ii)1 6225 109 202312 312022 [1993]045[2011]34810%H[2008]897HH10%H 202312 3126 2022 202312 312022 202312 312022 202312 312022 H 202312 31 2020 •2020 •2020 •20209 1820209 2814,509,4132021121320202020 •50%50%2433.33%33.33%33.34%362020 •20201.0 •20202020 2020 20226 27202220225 1120225 20 2022 20222022 2022202220226 27202210202220222022 20222022 2022 2022 H 2022519,900H0.21%20222022 202212 312022H1,500,000H20220.61% 2022H H1,500,000HH(i)2022(ii)2022 H0.61%2022HH 2022H2022 H10%H HH1% A H 2022 20