药明巨诺-B2023年度报告

2126JW (Cayman) Therapeutics Co. Ltd* 2023 目錄 24611144046101123128129130132133134200 Yiping James Li Yiping James LiKrishnan ViswanadhanDebra Yu Sungwon Song(1) Debra Yu(6)Krishnan Viswanadhan(2)Yiping James Li(7) Debra YuKrishnan Viswanadhan(2)Ann Li Lee(3) Yiping James Li 826 Ann Li Lee(3)(4)Debra YuSungwon Song(1) Maples Corporate Services LimitedPO Box 309, Ugland HouseGrand Cayman, KY1-1104Cayman Islands 1.20238 29SungwonSong20238 292.KrishnanViswanadhan20238293.Ann Li Lee20238 294.20238 295.20238 296.Debra Yu20238 297.Yiping James Li20238 29 ʮ̡༟ࣘ 17 699B5 22 131 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary Hall, Cricket SquareGrand Cayman, KY1-1102Cayman Islands 2126 www.jwtherapeutics.com 183171712–1716 2023 2023®19.3%20232022202240.3%202350.7%®®® 2023®20233®r/r LBCLIND20241®r/rMCLrelma-cel20234relma-celSLEIND ShaunPaul CordobaCAR-T 2023®98% ESG జѓࢩ˴ 1)®2)®3)4)5) Yiping James Li ࠅৌਕ࿜ 202312 31173.9202212 31145.719.3%CD19TCAR-T®relma-celJWCAR029®r/rBLBCLr/rFL® 202212 3158.850.1%202312 3188.2202212 3140.3%2023123150.7%® 202212 31190.940.7%202312 31113.2® 202212 31179.822.1%20231231140.0 202212 31407.81.4%202312 31413.6(i)(ii)2022 202312 31219.2202212 31159.6JWATM204/214181.220232022121.2 202312 31768.0202212 31846.1(i)®(ii)(iii)20232022(iv)(i)JWATM204/214(ii) ࠅৌਕ࿜ 202312 311,005.9202212 31451.1202312 31377.4 1 202212 31605.190.620231231514.5(i)®(ii)(iii) 業務摘要 202312 31®®r/r LBCLIND(i)®r/rMCL(ii)relma-celSLEIND®r/rMCLJWATM 214HCCIIT 2023 2023184®16820232023123150.7%202312 31®70105202312 3151%30%100% 20233®r/rLBCLIND202311 20241®r/rMCL®2022320231220231265 20233relma-celIITrelma-celSLE 20234relma-celSLEINDrelma-celSLE 20232JWATM214HCCIITJWATM214JWATM214JWATM204 Lyell T 2023A4MAGE-A4DeltaNotch3DLL320222seventy bio, Inc2seventybioJuno Therapeutics Inc.Juno ࠅุਕ࿜ CARBCAR TCARCAR ®98%LBCL 20222023 2023202312 31202312 31202217.3% 2016 CAR-T®JunoCAR-TCD19CAR-T®r/rLBCL24r/r FL®1CAR-TCAR-T 2023CAR-TCAR-TCAR-T2030CD19CAR-T2023®relma-celSLE 2023®2023184®168 ၍ଣᄴীሞၾʱؓ ®CAR-T®CAR-T202312 31125®® ®202312 31®701052023168®852023®51%30%100%®® 2020(i)1–2—(ii)2–3—(iii)3–5—20222022202312 31202312 31202217.3%50.7% CAR-TCAR-T2023CAR-T®CAR-T® 2023®relma-celSLE®r/rMCL2023122023112L LBCL®JWATM204HCCIITJWATM214HCCIIT 2023 2MAGE-A4DLL320233relma-celSLE20234relma-celSLEIND2seventy bio, Inc.2seventy bioCAR-T ၍ଣᄴীሞၾʱؓ LBCLBFLMCLALLCLLMMNHLSLE *1.Relma-celJunolisocabtagene maraleucel (Breyanzilisocabtagene liso-cel)CAR20212FDA2.JWCAR129Junoorvacabtagene autoleucel (orva-cel)CAR3.SLEB —®relma-celJWCAR029 ®CAR-TCD19LBCLFLNHLB®LBCLrelma-celNHLALLCLLr/rMCLLBCL® ®2JunoCARCARJunoBreyanzilisocabtageneliso-cel20212FDALBCL2022612LBCL LBCL 20219 1®r/rLBCL®1CAR-TCAR-T ®CAR-T®LBCLIIORR77.6%CRR53.5%5.1%sCRS3.4%sNTOS69.3%2023122024 LBCL I®LBCLI1293CRSNT3ORRCRR75.0%33.3%3ORRCRR41.7%33.3%OS20226 ၍ଣᄴীሞၾʱؓ 202112INDIII®LBCL+/-TRANSFORMBreyanzi®CARCAR-TBreyanziFDALBCL20223IND20231®r/rLBCLINDBreyanziFDABreyanzi20233IND2023112024 LBCL 20233®LBCLIITCD19CAR-T®IIITLBCLR-CHOP3100® LBCLILBCLIIT2024 FL 20209®r/rFL20222202210®r/r FLCAR-T ®r/r FL®r/r BRELIANCEB6320211263RELIANCEB®r/rFLORR=100.0%CRR=85.2%ORR=92.6%CRR=77.8%CAR-T 20221264®r/rFLIIRELIANCEB202112 17®2811.7®CRRORRORRCRR100.0%92.6%—3NT3CRSRELIANCE2024 r/r MCL ®CD-20BTKiMCLII®r/rMCL59CD-20BTKir/rMCL20241®r/rMCL®r/rMCL20224®202312 20231265®MCL20236 3056®42®CRRORRORR78.57%CRR66.67%®56≥3CRS5.36%≥3NT7.14%≥326.79% ALL I/IIr/rALL®20224IND®2024 ၍ଣᄴীሞၾʱؓ JWCAR129 JWCAR129MMCAR-TJunoCARH125MMBMMJWCAR129 BCMAMM202112JWCAR129r/r MMIND JWCAR129MM SLE SLEBSLE30/100,000270,000—440%SLE50% BBCDTSLE CD19BCD19CAR-TBCAR-T15,000CAR-T 20234relma-celSLEINDrelma-celrelma-celSLErelma-celIIRP2DSLE2024SLE SLECAR-TB NSCLCAFPGPC3-3r/rHASMAGE-A4A4DLL3 Delta3 * 1.JWATM204IJWATM203JWATM204CARINDI/II202111FDAJWATM203HBHCCHB20222FDAJWATM203JWATM204 2.Lyell ၍ଣᄴীሞၾʱؓ JWATM204/214 JWATM204-3GPC3ARTEMIS®E-ALPHA®HCCHLATTTCR-THCCJWATM204GPC3HCC202065JWJWATM204relma-cel2021JWATM20420227J W A T M204I I TH C CJWATM204 LyellLyellTJWATM204JWATM214HCC2022JWATM21420232JWATM214HCCIITJWATM214 JWATM203/213 JWATM203AFPHCCTTCRmT20206JWJWATM203JWATM204LyellTJWATM203ARTEMIS®JWATM213HCC JWTCR001 JWTCR001MAGE-A4MAGE-A4TCRMAGE-A4TCR-TRegeneronCTBR12TGF-betaFLIP6MAGE-A4TCR-TMAGE-A4BLA20241 31FDA 2022102seventy bioMAGE-A4MAGE-A42seventy bioMAGE-A4IIT2024 JWCAR031 JWCAR031DLL3CAR-TJunoJWNotchSCLCDLL3SCLCDLL380%SCLCDLL3 JunoJWCAR031Juno2022 12DLL3 18A.05® CD19CARCAR ၍ଣᄴীሞၾʱؓ CARCAR BCARTCAR2024BCAR2024 CAR2025 CAR 2020610,000GMPQMSTNKGMP 20213relma-celPAI20216AsAs+CsAMAHCCMOsGMPLBCL98%20222023 ®® ၍ଣᄴীሞၾʱؓ 202312 31202212 31 1. 202312 31173.9202212 31145.7CD19CAR-T®relma-celJWCAR029®r/r LBCLr/r FL®® 2. 202312 3185.6202212 3186.9 3. 202312 3188.250.7%202212 3158.840.3% ၍ଣᄴীሞၾʱؓ 4. 2022202312 31 202212 31190.9202312 31113.2®45.527.55.2 5. 2022202312 31 202212 31179.8202312 31140.029.45.1 6. 2022202312 31 20221