2 3 20 21 25 57 18323206 1617 CHEN Chuan • CHEN Chuan 1093 CHEN Chuan www.cspc.com.hk CHEN Chuan 2023 160.8020223.0% 31.6220223.0% 29.672022 202314202210202310 1220239 12 2,000ADCmRNAsiRNA PROTACAI (LNP)ADCPROTACLYTACAImRNAmRNAmRNAmRNACAR-TCAR-MsiRNA 10,000 1. 2023 2023129.340.355.2% ®®®®®® •®13 •® •® •®20233 •®2023 ®®®®®® •®NCCNCSCO® •® •®®2022 •®220221/T4CSCO/T2ANKT2BTB •®PI3K/PI3K ®B®®®/®®® ®20213BBB®®202112 •®® ®®TNK®®® •®2023® •®STEMI201902202212TNK®2022 •®20227 ®®®®®® •®SSc-ILDPF-ILD2022•®20227•®® ®®®/® ®/®® 2. 202319.709.6% •C10.4025.7%C•19.1%9.30 3. 202311.773.5% 4.mRNA 20233BA.5mRNASARS-CoV-2COVID-192-8°C410mRNA18513mRNA mRNA 5. 202323.0422.3%17.8%60816 •20233BA.5mRNASARS-CoV-2COVID-19•20233PD-1SG001PD-L1•20233B•20234DBPR1082•20236•20236HBM9161gMG•2023810 •20236 •20234CPO301•20236CPO301•20236CPO301 •20232®TNKrhTNK-tPATRACE-2The LancetIF202.731 •20233®III•20233SYSA1903H1III•20233CM310IL-4R/•20233CM326TSLP•20236ALMB-0168Cx432023ASCOIALMB-0168•20236SYSA1801CLDN18.2 ADCCLDN18.22023ASCOSYSA1801CLDN18.2 •2023PCT141226656301416 4060GLP1-IgD/IgG4 FcCX43ADCISACCD20/CD47mRNA 6. •20231Corbus Pharmaceuticals, Inc.SYS6002 (Nectin-4 ADC)7501.35.55 •20236/ 2023160.802022156.103.0%2.769.9%C 20232.4920222.331.2520220.980.6020220.65 20230.2020220.500.9120220.340.8520220.52 202349.02202254.109.4% 20235.3620225.655.2% 202323.04202218.8422.3% 20236.2420226.92 HKFRSHKFRSHKFRSHKFRSHKFRS –a–b– (a)(b)94,251,000202263,586,000 202313.20202242.5758202244103202210720236302.79.08 20236 30112.05202212 31104.9816.25202212 3135.750.75202212 311.8220236 300.2%2022 12 310.6% 20236 300.19 20236 30 20236 3025,587 2022352.9520236 30206,050,000 215620236 30343434 24102410 34 •20238 23 7 8910111317 12131415151617 (i)4,030,633,0002,631,198,000201210 296,661,831,000 (iii)(1)2012(2)2012(3)2016(4)2022 11 630 1. 343416 202212 31 662(3)63202212 31 406(2)407(2)(3) 2. 20236 30202212 31 202311 17202010 202221781212 2. 8 8 12 1220231120231231 1 2 202312 31 2. 12 12 202371220231 1 3.(i) 90 3. (i) (ii) (a)–(b)–C(c)–C 3. (ii) 3. 2022630 27,777 (9,722) 3,719,460 4. a (a)13,981,00020226 305,609,000202294,251,00020226 3063,586,000 20232022630 5. ––– 25%15%32025 21,319,628,000202212 3118,583,403,000 6. (a) 2023142022109.01,077,797,000 (b) 1110.12021108.6 7. 8. 9. 10. 11. 11. 26,554,00020226 3017,406,000 12. 90 09091180181365365 13. 14. 365202212 31365 15. 15. (II) cc 15. (a)(b)90202212 3190(c) 15. (III) 16. 1.90%2022 12 311.6%3.40%202212 313.50% 0.30%5.43%2022 12 310.30%3.33% 18. 09091180180 90202212 3190 19. 20. 202212 31365 21. ab a.b.3.7%5.5%2022 12 313.7%5.5% 22. 16,760,00014,706,000202112 23. (a) 20221302,904,000100%51% 82,22334,000962,5744,99230,5725,00024,9251,186(8,182)(255,642)(40)(46,790)(130,138)704,680 473,384,000 23. (a) 302,904473,384(704,680)71,608 302,904(1,186) 20226 3028,405,00027,342,000 20221 120226 30 24. (i) 201512 92025128 20231 120236 30591,101,840 (ii) 20188202028819 24. (ii) a.6.91b.6.55c.9.17d. 20231 120236 30120,304,368117,312,368 0.03% 20231 120236 3015,960,00054,464,000 (iii) 20224 120229 14218,250,0008,900,000352.95202320226 3020231 120236 30206,050,00020236 3094,251,000202263063,586,000 25. 26. ••• 20236 3010,979,00020226 308,365,000 26. 35220236 30XV (1)2,600,868,710(i)406,904,640(ii)1,218,834,470(iii)948,249,600(iv)26,880,000Harmonic Choice LimitedHarmonic Choice Limited75%15%10%40%60% 41 35220236 30 20236 30 33620236 30XV (1)2,600,868,710(i) 406,904,640(ii) 1,218,834,470(iii) 948,249,600(iv) 26,880,000Harmonic Choice LimitedHarmonic Choice Limited75%15%10%40%60% 3362023630 24 20236 3014 1020236 30 2023630 2023630 20236 30 20239 1120239 1220239 81617