Morgan Stanley Finance LLCSTRUCTURED INVESTMENTSOpportunities in U.S. Equities Market Linked Securities—Leveraged Upside Participation to a Cap and FixedPercentage Buffered Downside Principal at Risk Securities Linked to the Lowest Performing of the Dow Jones Industrial AverageSMandthe S&P 500®Indexdue June 22, 2029Fully and Unconditionally Guaranteed by Morgan Stanley ■If the level of the lowest performing underlyinghas increased, investors will receive the face amountplusa positive return equal to 150% of thepercentage increase in the level of the lowest performing underlying from its starting level, subject to a maximum return at maturity of at least 34.50%(to be determined on the pricing date) of the face amount. As a result of the maximum return, the maximum maturity payment amount will be at least$1,345 per security■If the level of the lowest performing underlying has decreased, but the lowest performing underlying has not decreased by more than 20%, investorswill receive the face amount■If the lowest performing underlying has decreased by more than the buffer amount, investors will have 1-to-1 downside exposure to the decrease in thelevel of the lowest performing underlyingfrom its starting level in excess of the buffer amount ■The securities are for investors who seek an equity index-based return and who are willing to risk their investment, risk exposure to the lowest performingunderlying and forgo current income and upside above the maximum return in exchange for the participation rate and buffer features that in each case apply to alimited range of performance of the lowest performing underlying■The securities are notes issued as part of MSFL’s Series A Global Medium-Term Notes program■All payments are subject to our credit risk. If we default on our obligations, you could lose some or all of your investment■These securities are not secured obligations and you will not have any security interest in, or otherwise have any access to, any securities included inany of the underlyings The current estimated value of the securities is approximately $960.80 per security, or within $30.00 of that estimate. The estimated value of thesecurities is determined using our own pricing and valuation models, market inputs and assumptions relating to the underlyings, instrumentsbased on the underlyings, volatility and other factors including current and expected interest rates, as well as an interest rate related to oursecondary market credit spread, which is the implied interest rate at which our conventional fixed rate debt trades in the secondary market. See“Estimated Value of the Securities” on page 3. The securities have complex features and investing in the securities involves risks not associated with an investment in ordinarydebt securities. See “Risk Factors” beginning on page 11. All payments on the securities are subject to our credit risk. The Securities and Exchange Commission and state securities regulators have not approved or disapproved these securities, or determined if thisdocument or the accompanying product supplement, index supplement, tax supplement and prospectus is truthful or complete. Anyrepresentation to the contrary is a criminal offense.The securities are not deposits or savings accounts and are not insured by the Federal Deposit Insurance Corporation or any other governmental agency or instrumentality, nor are they obligations of, or guaranteed by, a bank.You should read this document together with the related product supplement for principal at risk securities, index supplement, tax supplement and prospectus, each of which can be accessed via the hyperlinks below. Please also see “Additional Information About the Securities” at the endof this document.As used in this document, “we,” “us” and “our” refer to Morgan Stanley or MSFL, or Morgan Stanley and MSFL collectively, as the context requires. Morgan StanleySecurities Morgan Stanley Finance LLC Market Linked Securities—Leveraged Upside Participation to a Cap and Fixed Percentage BufferedDownside Principal at Risk Securities Linked to the Lowest Performing of the Dow Jones Industrial AverageSMand the S&P 500®Index due June 22, 2029 * Subject to postponement pursuant to “General Terms of the Securities—Payment Dates” in the accompanying product supplement for principal at risk securities.** Subject to postponement pursuant to “General Terms of the Securities—Consequences of a Market Disruption Event; Postponement of a Calculation Day” in theaccompanying product supplement for principal at risk securities. June 2026Page 2 Morgan Stanley Finance LLC Market Linked Securities—Leveraged Upside Participation to a Cap and Fixed Percentage BufferedDownsidePrincipal at Risk Securities Linked to the Lowest Performing of the Dow Jones Industrial AverageSMand the S&P 500®Index due June 22, 2029 Estimated Value of the Securities The face amount of each security is $1,000. This price includes costs associated with issuing, selli