安进 2025年度报告

FORM 11-K (Mark One) ANNUALREPORT PURSUANT TO SECTION 15(d)OF THE SECURITIESEXCHANGE ACT OF1934 For the fiscal year ended December31, 2025 OR TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIESEXCHANGE ACT OF 1934 Commission file number 001-37702 RETIREMENT AND SAVINGS PLAN FORAMGEN MANUFACTURING LIMITED LLC State Road 31, Kilometer 24.6, Juncos, Puerto Rico 00777(Full title and address of the plan) AMGEN INC.(Name of issuer of the securities held) 91320-1799(Zip Code) One Amgen Center Drive,Thousand Oaks, California(Address of principal executive offices) Retirement and Savings Plan forAmgen Manufacturing Limited LLC Audited Financial Statementsand Supplemental Schedule Year Ended December31, 2025 Contents Report of Independent Registered Public Accounting Firm Audited Financial Statements: Statements of Net Assets Available for Benefits at December31, 2025 and 2024Statement of Changes in Net Assets Available for Benefits for the year ended December31, 2025Notes to Financial Statements Supplemental Schedule: Schedule of Assets (Held at End of Year)10 Index to ExhibitSignatures Report of Independent Registered Public Accounting Firm To the Plan Participants and the Plan Administrator of the Retirement and Savings Plan for Amgen Manufacturing Limited LLC Opinion on the Financial Statements We have audited the accompanying statements of net assets available for benefits of the Retirement and Savings Plan for AmgenManufacturing Limited LLC (the Plan) as of December 31, 2025 and 2024, and the related statement of changes in net assets availablefor benefits for the year ended December 31, 2025, and the related notes (collectively referred to as the “financial statements”). In ouropinion, the financial statements present fairly, in all material respects, the net assets available for benefits of the Plan at December 31,2025 and 2024, and the changes in its net assets available for benefits for the year ended December31, 2025, in conformity with U.S.generally accepted accounting principles. Basis for Opinion These financial statements are the responsibility of the Plan’s management. Our responsibility is to express an opinion on the Plan’sfinancial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting OversightBoard (United States) (PCAOB) and are required to be independent with respect to the Plan in accordance with the U.S. federalsecurities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB. We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the auditto obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud.The Plan is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part ofour audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressingan opinion on the effectiveness of the Plan’s internal control over financial reporting. Accordingly, we express no such opinion. Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due toerror or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidenceregarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles usedand significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believethat our audits provide a reasonable basis for our opinion. Supplemental Schedule Required by ERISA The accompanying supplemental schedule of assets (held at end of year) as of December 31, 2025, (referred to as the “supplementalschedule”), has been subjected to audit procedures performed in conjunction with the audit of the Plan’s financial statements. Theinformation in the supplemental schedule is the responsibility of the Plan’s management. Our audit procedures included determiningwhether the information reconciles to the financial statements or the underlying accounting and other records, as applicable, andperforming procedures to test the completeness and accuracy of the information presented in the supplemental schedule. In formingour opinion on the information, we evaluated whether such information, including its form and content, is presented in conformitywith the Department of Labor’s Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income SecurityAct of 1974. In our opinion, the information is fairly stated, in all material respects, in relation to the financial statements as a whole. /s/ ERNST & YOUNG LLP Retirement and Savings Plan for Amgen Manufacturing Limited LL