MeiraGTx Holdings plc美股招股说明书(2026-04-16版)

Ordinary Shares We are offering 11,111,111 of our ordinary shares, nominal value $0.00003881 per ordinary share. Our ordinary shares are listed on the Nasdaq Global Select Market under the symbol “MGTX.” OnApril15, 2026, the last reported sale price of our ordinary shares on the Nasdaq Global Select Market was$11.25 per ordinary share. We are a “smaller reporting company” under applicable Securities and Exchange Commission rulesand, as such, have elected to comply with certain reduced public company disclosure requirements for thisprospectus and future filings. See “Prospectus Summary — Implications of Being a Smaller ReportingCompany.” Investing in our ordinary shares involves risk. See “Risk Factors” on pageS-6of this prospectus supplement,on page6of the accompanying base prospectus and our filings with the Securities and Exchange Commission, orthe SEC, that are incorporated by reference herein and therein to read about factors you should consider beforeinvesting in our ordinary shares. (1)We refer you to “Underwriting” beginning on page S-20 for additional information regardingunderwriting compensation. Neither the SEC nor any state securities commission has approved or disapproved of these securities ordetermined if this prospectus supplement or the accompanying prospectus is truthful or complete. Anyrepresentation to the contrary is a criminal offense. The ordinary shares will be ready for delivery on or about April17, 2026. Joint Book-Running Managers BofA Securities Co-Manager Raymond James The date of this prospectus supplement is April16, 2026. TABLE OF CONTENTS PagePROSPECTUS SUPPLEMENTABOUT THIS PROSPECTUS SUPPLEMENTS-1WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY REFERENCES-2SUMMARYS-4THE OFFERINGS-5RISK FACTORSS-6CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTSS-7USE OF PROCEEDSS-8DIVIDEND POLICYS-9DILUTIONS-10MATERIAL CAYMAN ISLANDS TAX CONSIDERATIONSS-11MATERIAL UNITED KINGDOM TAX CONSIDERATIONSS-12MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES TO U.S. HOLDERSS-15UNDERWRITINGS-20LEGAL MATTERSS-27EXPERTSS-27 Page ABOUT THIS PROSPECTUS1SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS2WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY REFERENCE3PROSPECTUS SUMMARY5RISK FACTORS6USE OF PROCEEDS7DESCRIPTION OF SHARE CAPITAL8DESCRIPTION OF WARRANTS16DESCRIPTION OF PURCHASE CONTRACTS17DESCRIPTION OF UNITS18GLOBAL SECURITIES19PLAN OF DISTRIBUTION23LEGAL MATTERS25EXPERTS25 ABOUT THIS PROSPECTUS SUPPLEMENT This prospectus supplement is part of a registration statement that we have filed with the SEC utilizinga “shelf” registration process, and relates to the offering of our ordinary shares. Before buying any of theordinary shares that we are offering, we urge you to carefully read this prospectus supplement, theaccompanying base prospectus and all of the information incorporated by reference herein and therein, aswell as the additional information described under the heading “Where You Can Find More Information;Incorporation by Reference” in this prospectus supplement. These documents contain important informationthat you should consider when making your investment decision. We provide information to you about this offering of our ordinary shares in two separate documentsthat are bound together: (1)this prospectus supplement, which describes the specific details regarding thisoffering; and (2)the accompanying base prospectus, which provides general information, some of whichmay not apply to this offering. Generally, when we refer to this “prospectus,” we are referring to bothdocuments combined. If information in this prospectus supplement is inconsistent with the accompanyingbase prospectus, you should rely on this prospectus supplement. To the extent there is a conflict between theinformation contained in this prospectus supplement, on the one hand, and the information contained in anydocument incorporated by reference in this prospectus supplement, on the other hand, you should rely onthe information in this prospectus supplement. If any statement in one of these documents is inconsistentwith a statement in another document having a later date — for example, a document incorporated byreference in this prospectus supplement — the statement in the document having the later date modifies orsupersedes the earlier statement. Neither we nor the underwriters have authorized anyone to provide any information or make anyrepresentations other than those contained or incorporated by reference in this prospectus supplement, theaccompanying prospectus or any free writing prospectus that we have authorized for use in connection withthis offering. We take no responsibility for, and can provide no assurance as to the reliability of, any otherinformation that others may give you. Neither we nor any of the underwriters are making an offer to sellthese securities in any jurisdiction where the offer or sale is not permitted or in which the person makingthat offer or solicitation is not q