Southern First Bancshares Inc美股招股说明书(2026-04-15版)

The information in this preliminary prospectus supplement relates to an effective registration statement, but is not complete and maybe changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell securities and are notsoliciting an offer to buy these securities in any state or jurisdiction where the offer or sale is not permitted. Filed Pursuant to Rule 424(b)(5)Registration Statement Number 333-293279 Subject to Completion dated April 15, 2026 Preliminary Prospectus SupplementTo the Prospectus Dated February 6, 2026 Shares Common Stock We are offeringshares of our common stock, par value $0.01 per share, at a public offering price of $pershare. Our common stock is traded on The Nasdaq Global Market under the symbol “SFST.” On April 14, 2026, the last reported saleprice of our common stock on The Nasdaq Global Market was $58.85 per share. Investing in our common stock involves risks. Please carefully read the “Risk Factors” beginning on page S-9 of thisprospectus supplement and appearing in our Annual Report on Form 10-K for the period ended December 31, 2025 for adiscussion of certain factors that you should consider before making your investment decision. Public offering priceUnderwriting discount(1)Proceeds to us, before expenses (1)See “Underwriting” beginning on page S-16 for disclosure regarding the underwriting discounts, expenses payable to theunderwriters and proceeds to us, before expenses. The shares of our common stock are being offered through the underwriters on a firm commitment basis. We have granted theunderwriters the right to purchase up toadditional shares of our common stock at the public offering price, less theunderwriting discount. If the underwriters exercise their option in full, the total underwriting discounts and commissions payable by uswill be $and the total proceeds to us, before expenses, will be $. Table of Contents Neither the U.S. Securities and Exchange Commission nor any state securities commission has approved ordisapproved of these securities or passed upon the adequacy of this prospectus. Any representation to the contrary is acriminal offense in the United States. These securities are not deposits or other obligations of any of our bank or non-bank subsidiaries and are not insuredby the Federal Deposit Insurance Corporation or any other governmental agency. The underwriters expect to deliver the shares of our common stock in book-entry form only, through the facilities of TheDepository Trust Company, against payment on or about April, 2026, subject to customary closing conditions. Sole Book-Running Manager Co-Manager The date of this prospectus supplement is April, 2026. Southern First Bancshares, Inc. TABLE OF CONTENTS Prospectus Supplement About This Prospectus SupplementSpecial Note Regarding Forward-Looking StatementsProspectus Supplement SummaryThe OfferingRisk FactorsUse of ProceedsCapitalizationDescription of Our Capital StockUnderwritingLegal MattersExpertsWhere You Can Find More InformationIncorporation of Certain Information by Reference Prospectus About this ProspectusIncorporation of Certain Information by ReferenceRisk FactorsSpecial Note Regarding Forward-Looking StatementsProspectus SummarySouthern First Bancshares, Inc.Use of ProceedsPlan of DistributionDescription of Debt SecuritiesDescription of Preferred StockDescription of Depositary SharesDescription of Common StockDescription of Purchase ContractsDescription of UnitsDescription of WarrantsDescription of RightsAnti-Takeover Effects of Certain Articles of Incorporation ProvisionsValidity of SecuritiesExpertsWhere You Can Find More Information Table of Contents In making your investment decision, you should rely only on the information contained or incorporated by referencein this prospectus supplement, the accompanying prospectus and any free writing prospectus that we have authorized and filedby us with the SEC. We have not, and the underwriters have not, authorized anyone else to provide you with different oradditional information. If anyone provides you with any other information, you should not rely on it. We are not, and theunderwriters have not, making an offer to sell these securities in any jurisdiction where the offer and sale is not permitted. Youshould not assume that the information in this prospectus supplement, the accompanying prospectus, any free writingprospectus or any document incorporated by reference is accurate as of any date other than its respective date. Our business,financial condition, results of operations and prospects may have changed since those dates. This prospectus supplement is not complete without, and may not be delivered or utilized except in connection with,the accompanying prospectus. This prospectus supplement supersedes the accompanying prospectus to the extent it containsinformation that is different from or in addition to the information in that prospectus. Any information in the acc