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Equinix Canada FinancingLtd. C$700,000,000 4.000% Senior Notes due 2032Unconditionally Guaranteed by Equinix,Inc. Equinix Canada FinancingLtd. (the “Issuer”), an indirect, wholly-owned subsidiary of Equinix,Inc., is offering C$700,000,000aggregate principal amount of 4.000% Senior Notes due 2032 (the “notes”). Interest will accrue on the notes from November 24, 2025.Interest will be payable semi-annually on May15 and November15 of each year, commencing May 15, 2026, provided that the initial interestpayment will be C$18.85 per C$1,000 of principal amount of the notes (short first coupon). The Issuer may redeem the notes in whole or inpart at any time or from time to time at the redemption prices described under “Description of Notes — Optional Redemption,” which includeaccrued and unpaid interest thereon, if any, to, but not including, the redemption date. In addition, in the event of certain developmentsaffecting taxation, we may redeem the notes, in whole but not in part, at our option, at a redemption price equal to 100% of their principalamount, plus accrued and unpaid interest, if any, thereon to, but excluding, the redemption date. See the section titled “Description of Notes— Redemption upon a Tax Event.” Depending on when such notes are redeemed, a make-whole premium may or may not be payable inrespect of any such redemptions. The notes will be the Issuer’s unsecured senior obligations and will rank equal in right of payment to all of the Issuer’s future unsecuredand unsubordinated indebtedness and structurally subordinated to all of the liabilities of the Issuer’s subsidiaries, if any. In addition,Equinix,Inc.’s obligations under the guarantee will rank equally with all of its other unsecured and unsubordinated indebtedness and will beeffectively subordinated to all of the existing and future secured indebtedness of Equinix,Inc. and structurally subordinated to all of theindebtedness and liabilities of other subsidiaries of Equinix,Inc. Upon a change of control triggering event, the Issuer will be required tomake an offer to purchase each holder’s notes at a purchase price equal to 101% of the principal amount thereof plus accrued and unpaidinterest to the date of purchase. The notes will not be listed on any securities exchange or automated dealer quotation system. Currently there is no public market for thenotes. Investing in the notes involves risks. See “Risk Factors” beginning on pageS-11of this prospectus supplement, as well as the risks described in“Risk Factors” in our most recent Quarterly Report on Form10-Q, which is incorporated by reference into this prospectus supplement and theaccompanying prospectus. Neither the Securities and Exchange Commission (the “SEC”) nor any state securities commission has approved or disapproved of thesesecurities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense. The Issuer expects to deliver the notes in book-entry form through the facilities of CDS Clearing and Depository ServicesInc. (“CDS”)against payment in New York, New York on or about November 24, 2025, which is the fifth Toronto and fifth New York business dayfollowing the date of this prospectus supplement (this settlement cycle is referred to as “T+5”). Purchasers of the notes should note thattrading of the notes may be affected by the settlement date. The notes will be sold in Canada on a private placement basis to “accredited investors” who, in certain circumstances, are also“permitted clients”, each as defined under applicable Canadian securities laws. See “Underwriting — Selling Restrictions — Canada.” TABLE OF CONTENTS Prospectus Supplement PageAbout This Prospectus SupplementS-1Forward-Looking StatementsS-3SummaryS-4Risk FactorsS-11Currency ConversionS-19Use of ProceedsS-20CapitalizationS-21Description of NotesS-23Material U.S. Federal Income Tax ConsiderationsS-53UnderwritingS-58Legal MattersS-64ExpertsS-64Where You Can Find More InformationS-64 Prospectus PageEquinix1About This Prospectus1Forward-Looking Statements1Where You Can Find More Information2Incorporation By Reference2Risk Factors3Use of Proceeds4Description of Capital Stock5Description of Debt Securities11Description of Depositary Shares12Description of Warrants13Description of Purchase Contracts14Description of Units15Plan of Distribution16Legal Matters18Experts18 ABOUT THIS PROSPECTUS SUPPLEMENT This document consists of two parts. The first part is this prospectus supplement, which describes thespecific terms of this offering and the notes offered hereby, and also adds to and updates the informationcontained or incorporated by reference in the accompanying prospectus. The second part is the prospectus,which describes more general information regarding our securities, some of which does not apply to thisoffering. You should read both this prospectus supplement and the accompanying prospectus, together withadditional information described under th