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GLOBAL INFLUENZA SURVEILLANCE AND RESPONSE SYSTEM (GISRS) RSV SARS-CoV-2 Influenza Co-circulation SUMMARY (Based on data reported to WHO for week 40, ending 05 October 2025) Globally, influenza and SARS-CoV-2 activity remained low in week 40. At these low levels of circulation, SARS-CoV-2 predominated, with percent positivityincreasing gradually in recent weeks. SARS-CoV-2 predominated in the temperate and subtropical areas of the northern hemisphere, whereas influenza wasmore predominant in tropical areas, with influenza positivity reported above 10%, and in the temperate and subtropical areas of the southern hemispherewhere influenza percent positivity was below 10%. [Figures 1a, 1b, 1c and 1d] qInfluenza Globally, influenza activity remained low, with influenza A viruses continuing to predominate. Different patterns were observed across hemispheresand transmission zones. [Figure 2] In the northern hemisphere, over the past few weeks, influenza activity remained low and stable in most transmission zones in the temperatenorthern hemisphere.Influenza positivity was elevated in Central America and the Caribbean, Western, Northern, Eastern and Middle Africa,Western, Southern and South-East Asia and percent positivity was over 30% in countries in South-East Asia and Western Africa. An increasein activity was observed in countries in Central America and the Caribbean, Western and Eastern Africa, Western and South-East Asia. [Figures 3 and 4] In the southern hemisphere, influenza activity remained low and stable in most reporting countries with elevated positivity (>10%) observed in singlecountries in Temperate South America, Eastern Africa, and percent positivity over 30% in single countries in South-East Asia and Oceania. Anincrease in activity was observed in a single country in South-East Asia. [Figures 3 and 4] In the transmission zones with elevated positivity, influenza A(H1N1)pdm09 predominated in Central America and the Caribbean, Eastern andMiddle Africa whilst influenza A(H3N2) was the predominant circulating subtype in Temperate South America, Western, Southern and South-EastAsia and Oceania. Influenza A(H1N1)pdm09 and influenza A(H3N2) were codominant in Western Africa. [Figures 5 and 6] qSARS-CoV-2Globally, SARS-CoV-2 positivity increased but remained at low levels, with some countries reporting elevated positivity (>10%) in North America, Central America and the Caribbean, Tropical South America, Europe, Western and Eastern Asia and percent positivity was over 30% in a fewcountries. Small increases in activity were reported in two countries in South-West Europe and one country in Tropical South America. [Figures 7 and8] qRespiratory Syncytial Virus (RSV)RSV positivity remained elevated in some countries in Central America and the Caribbean, Tropical and Temperate South America, Western Africa and Southern Asia and percent positivity was over 30% in a few countries. RSV positivity remained stable across the majority of reporting countries,with increases in activity reported in a few countries in Central America and the Caribbean. [Figures 9 and 10] Co-circulation of influenza and SARS-CoV-2 1a) Weekly numbers of influenza and SARS-CoV-2 virus specimens tested and percent positivity at the global level(last 12 months) 1c) Weekly numbers of influenza andSARS-CoV-2 virus specimens tested andpercent positivity in Tropical areas 1b) Weekly numbers of influenza andSARS-CoV-2 virus specimens tested andpercent positivity in Northern hemispheretemperate and subtropical areas 1d) Weekly numbers of influenza andSARS-CoV-2 virus specimens tested andpercent positivity in Southern hemispheretemperate and subtropical areas Influenza 2) Weekly numbers of influenza virus positive specimens by type and subtype and percent positivity at the globallevel (last 12 months) 4) Change in proportions of specimens that testedpositive for influenza (year-week:2025-40) 3) Proportions of specimens that tested positive forinfluenza (year-week:2025-40) 6) Weekly distribution of influenza virus types andsubtypes by geographic zone (last 12 months) 5) Proportions of influenza virus types and subtypes byinfluenza transmission zones (year-week:2025-40) SARS-CoV-2 8) Change in proportions of specimens that testedpositive for SARS-CoV-2 (year-week:2025-40) 7) Proportions of specimens that tested positive forSARS-CoV-2 (year-week:2025-40) Respiratory syncytial virus 9) Proportions of specimens that tested positive for RSV(year-week:2025-40) 10) Change in proportions of specimens that testedpositive for RSV (year-week:2025-40) Additional information Data and methods The data presented in this report originates from virologic surveillance conducted by countries, areas, and territories (CATs) andsubmitted to WHO FluNet through participation or collaboration with the Global Influenza Surveillance and Response System(GISRS). These CATs employ diverse methodologies to monitor respiratory virus activity, whic