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$900,000,000 4.050% Notes due 2027$300,000,000 Floating Rate Notes due 2028$850,000,000 4.150% Notes due 2028$850,000,000 4.400% Notes due 2030 Hewlett Packard Enterprise Company (“Hewlett Packard Enterprise,” “HPE,” “we” or “us”) is offering $900,000,000 aggregateprincipal amount of its 4.050% notes due 2027 (the “2027 notes”), $300,000,000 aggregate principal amount of its floating rate notesdue 2028 (the “floating rate notes”), $850,000,000 aggregate principal amount of its 4.150% notes due 2028 (the “2028 notes”) and$850,000,000 aggregate principal amount of its 4.400% notes due 2030 (the “2030 notes”). We refer to the 2027 notes, the 2028notes, and the 2030 notes collectively as the “fixed rate notes,” and we refer to the floating rate notes and the fixed rate notescollectively as the “notes.” The 2027 notes will bear interest at a rate of 4.050% per annum. The floating rate notes will bear interest at a floating rate equalto a benchmark rate, which will initially be Compounded SOFR (as defined herein), plus a spread of 0.96% per annum. The 2028notes will bear interest at a rate of 4.150% per annum. The 2030 notes will bear interest at a rate of 4.400% per annum. We will pay interest semi-annually on the 2027 notes on each March 15 and September 15, beginning on March 15, 2026. Wewill pay interest on the floating rate notes on each March 15, June 15, September 15 and December 15, beginning on December 15,2025. We will pay interest semi-annually on the 2028 notes on each March 15 and September 15, beginning on March 15, 2026. Wewill pay interest semi-annually on the 2030 notes on each April 15 and October 15, beginning on April 15, 2026. The 2027 notes will mature on September 15, 2027. The floating rate notes will mature on September 15, 2028. The 2028 noteswill mature on September 15, 2028. The 2030 notes will mature on October 15, 2030. If a Change of Control Repurchase Event (as defined herein) with respect to a series of notes occurs, we may be required tooffer to purchase such series of notes from holders. See “Description of the Notes—Repurchase at the Option of Holders on CertainChanges of Control.” The notes will be our senior unsecured obligations and will rank equally with all of our other existing and futuresenior unsecured indebtedness. There is no sinking fund for any series of notes. The notes are not and will not be listed on anysecurities exchange or quoted on any automated quotation system. Investing in the notes involves certain risks. You should carefully consider all the information contained or incorporatedby reference in this prospectus supplement prior to investing in the notes. In particular, we urge you to carefully consider theinformation set forth in the section titled “Risk Factors” beginning on page S-8of this prospectus supplement. (1)Plus accrued interest, if any, from September 15, 2025 if settlement occurs after that date. Neither the Securities and Exchange Commission (the “SEC”) nor any state securities commission has approved ordisapproved of these securities or determined if this prospectus supplement or the prospectus to which it relates is truthful orcomplete. Any representation to the contrary is a criminal offense. Delivery of the notes in book-entry form only will be made through The Depository Trust Company for the benefit of its directand indirect participants, including Clearstream Banking,société anonyme, and Euroclear Bank S.A./N.V., on or about September 15,2025. TABLE OF CONTENTS Prospectus Supplement PageABOUT THIS PROSPECTUS SUPPLEMENTS-1FORWARD-LOOKING STATEMENTSS-2SUMMARYS-4THE OFFERINGS-6RISK FACTORSS-8USE OF PROCEEDSS-14DESCRIPTION OF THE NOTESS-15CERTAIN UNITED STATES FEDERAL INCOME TAX CONSIDERATIONSS-33CERTAIN ERISA CONSIDERATIONSS-37UNDERWRITINGS-39VALIDITY OF THE NOTESS-44EXPERTSS-44WHERE YOU CAN FIND MORE INFORMATIONS-44INFORMATION INCORPORATED BY REFERENCES-45 PageABOUT THIS PROSPECTUS1ABOUT THE COMPANY1FORWARD-LOOKING STATEMENTS2USE OF PROCEEDS3DESCRIPTION OF THE DEBT SECURITIES4DESCRIPTION OF CAPITAL STOCK12DESCRIPTION OF OTHER SECURITIES14PLAN OF DISTRIBUTION15VALIDITY OF THE SECURITIES16EXPERTS16WHERE YOU CAN FIND MORE INFORMATION16INFORMATION INCORPORATED BY REFERENCE17 You should rely only on the information contained or incorporated by reference in this prospectussupplement, in the accompanying prospectus, or in any free writing prospectus filed by us with the SEC. Wehave not, and the underwriters have not, authorized anyone to provide you with different information. Weare not, and the underwriters are not, making an offer of the notes covered by this prospectus supplement inany jurisdiction where the offer is not permitted. The information contained or incorporated by reference inthis prospectus supplement or the accompanying prospectus is accurate only as of their respective dates,regardless of the time of delivery of this prospectus supplement and the accompanying prospectus, or of anysale of the notes. You should not