使用非靶向分析测定电子液体中风味剂的标准操作程序：气相色谱-质谱法：世界卫生组织TobLabNet官方方法SOP 16

SuSingnon-Spectrometry Standard operating procedure for thedetermination of flavouring agents ine-liquids using non-targeted analysis: gaschromatography mass spectrometry Standard operating procedure for the determination of flavouring agents in e-liquids using non-targeted analysis:gas chromatography mass spectrometry. WHO TobLabNet Official Method SOP16ISBN 978-92-4-011150-9 (electronic version)ISBN 978-92-4-011151-6 (print version)© World Health Organization 2025Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes,provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestionthat WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If youadapt the work, then you must license your work under the same or equivalent Creative Commons licence. If youcreate a translation of this work, you should add the following disclaimer along with the suggested citation: “Thistranslation was not created by the World Health Organization (WHO). WHO is not responsible for the content oraccuracy of this translation. The original English edition shall be the binding and authentic edition”.Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediationrules of the World Intellectual Property Organization (http://www.wipo.int/amc/en/mediation/rules).Suggested citation.Standard operating procedure for the determination of flavouring agents in e-liquids using non-targeted analysis: gas chromatography mass spectrometry. WHO TobLabNet Official Method SOP16. Geneva: WorldHealth Organization; 2025. Licence: CC BY-NC-SA 3.0 IGO.Cataloguing-in-Publication (CIP) data.CIP data are available at http://apps.who.int/iris.Sales, rights and licensing.To purchase WHO publications, see https://www.who.int/publications/book-orders.To submit requests for commercial use and queries on rights and licensing, see https://www.who.int/copyright.Third-party materials.If you wish to reuse material from this work that is attributed to a third party, such as tables,figures or images, it is your responsibility to determine whether permission is needed for that reuse and to obtainpermission from the copyright holder. The risk of claims resulting from infringement of any third-party-ownedcomponent in the work rests solely with the user.General disclaimers.The designations employed and the presentation of the material in this publication do notimply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any country,territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted anddashed lines on maps represent approximate border lines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsedor recommended by WHO in preference to others of a similar nature that are not mentioned. Errors and omissionsexcepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by WHO to verify the information contained in this publication.However, the published material is being distributed without warranty of any kind, either expressed or implied. Theresponsibility for the interpretation and use of the material lies with the reader. In no event shall WHO be liable fordamages arising from its use. ContentsForewordIntroduction1.Scope2.References3Termsanddefinitions4.Method summary5.Safety and environmental precautions6.Apparatus and equipment7.Reagents and supplies8.Preparation of glassware9.Preparation of solutions10.Preparation of standards11.Sampling12.Product preparation13.Preparation of the smoking machine14.Sample generation15.Sample preparation16.Sample analysis17.Data analysis and calculations18.Special precautions19.Data reporting20.Quality control21.Methodperformancespecifications22.Repeatability and reproducibility23.BibliographyAnnex 1Descriptionofverificationandsemi-quantitativedeterminationAnnex 2Verificationoftheidentifiedanalyteandsemi-quantitativedeterminationAnnex 3SPME determination 11122233444445777710111111121214151719 Standard operating procedure for the determination of flavouring agents in e-liquids using non-targeted analysis— gas chromatography mass spectrometry. WHO TobLabNet Official Method SOP16No.:SOP 16Date:April 2025Standard operating procedure for thedetermination of flavouring agents ine-liquids using non-targeted analysis:gas chromatography mass spectrometryWHO TobLabNet Official Method SOP16Determinationofflavouringagentsine-liquidsusingnon-targeted analysis (NTA) – GC-MS method Method