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Top insights from Citeline experts 10 Ways to Set Up Your Sites for Recruitment Success Recruitment is arguably a clinical trial site’s greatest challenge. Taking the following steps can better support your sites to be more effective in recruitingthe necessary patients needed to make your trial a success. Select the right sites1 Use all data at your disposal to ensure you choose sites with therightexperience, patient population, diversity mix, and timelines. Make sure youspend time on yoursite qualification/feasibility outreachto ensure theytreat the relevant patient population. It is also important to find out how toavoid the rate-limiting processesthat delay site opening (e.g., contracts, EC submissions, etc.). Finally, do nothesitate touse unknown siteswith less experience. Often these sites havethe motivation, patient population, and capacity to really deliver. Think about recruitment at the time of protocol creation2 From the moment you begin to create your protocol, you will want to make sure you resolve as manypotential issues with recruitment as you can before they arise. Ask your team: Are youreligibilitycriteria viable?Are the visit schedule and/orprocedures burdensome? Is there arobust feedbackprocessby which sites can communicate difficulties with recruitment and/or I/E criteria? Involve key opinion leaders (KOLs) and sites early in protocol development3 It is important to get KOLs and sites involved in planning early in the process of developing yourprotocol. This will help youavoid protocol amendmentsdown the line. Choose sites with experience in your preferred technology4 If a site manages several trials and uses multiple new systems to navigate,low bandwidth can slow patient recruitment.Make sure youdiscussthe technologythe sites are accustomed to using (e.g., EDC, ePRO, IVRS,etc.) before you reach an agreement. And once you have selected your sitepartner, try tooffer enough supportin your technology for ease of use. Provide sites with the high-quality materials they need for outreach at the start5 From the beginning, make sure you discuss what types of patient outreach the sites will be conducting(e.g., print materials, multiple social media/digital options, etc.). That way, you cantailor materialstosuit each form of outreach. It is also helpful to makenon-English materialsavailable at the start tohelp ensure diverse recruitment. Keep in mind that sites know what works best with their communities and may need tosupplementwith additional materialsto ensure the study is a success. 10 Ways to Set Up Your Sites for Recruitment Success Offer sites enrollment optimization support services for any externalrecruitment campaigns6 These are typically part ofpatient recruitment vendors’ solutionswhen delivering referrals. Forexample, you will want to providea defined processfor sites processing prescreened, qualifiedreferrals received by recruitment campaigns. You will also need to offermedical records retrievalservicesto support additional qualification review for externally sourced, prescreened referrals. Train sites on processes/technologies for receiving prequalified referrals fromexternal patient recruitment campaigns7 Collaborate with sites toidentify any referral pathwaysthat can be supported throughtechnology/sponsor-partner support. Ensure timely patient payments8 This is vital, as sites are the ones that must field these complaints, which adds to their burden. Beinglate with payments can alsoaffect patient retention. Consider involving patient advocacy groups with established site relationships Ask sites if they work with patient advocacy groups you couldjointly contactto inform their patientsof potential clinical trial opportunities. Remunerate sites for external patient recruitment campaigns Sponsor/CRO-site contracts typically do not cover the costs associated withadditional staff timerequired to process externally sourced referrals, which puts further economic stress on sites. So,make sure topay sites for time/resourcesdedicated to contacting, processing, and evaluatingany prequalified referrals received from external patient recruitment campaigns. Citeline Connect, your complete patient recruitment solution Citeline Connect fuels clinical trial education and engagement toprevent patient drop-off and reduce the burden of enrollment for allstakeholders. It revolutionizes how patients find and enroll in clinicalresearch across the globe by combining the power of data-driventechnology with the reach of proprietary HCP networks and 100+pre-vetted partners from an industry-first patient referral collective. Meet our experts Claire Riches As VP, Clinical Solutions, Claire ensures Citeline’s data, newproducts, and services are meeting the needs and solving thechallenges of the clinical industry. With over 25 years’ experiencein the pharma industry within both clinical research andcommercial strategy, Claire’s broad career encompasses multipleclinical fields, proje