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RiverNorth/DoubleLine Strategic Opportunity Fund, Inc. (the “Fund”) has entered into a distribution agreement,dated May 20, 2025 (the “Distribution Agreement”), with ALPS Distributors, Inc. (the “Distributor”) relating to the Fund’sshares of common stock, $0.0001 par value per share (the “Common Shares”), offered by this Prospectus Supplement andthe accompanying Prospectus. In accordance with the terms of the Distribution Agreement, the Fund may offer and sell upto 10,000,000 of the Fund’s Common Shares from time to time through the Distributor. Under the Investment CompanyAct of 1940, as amended (the “1940 Act”), the Fund may not sell any Common Shares at a price below the current netasset value (“NAV”) of such Common Shares, exclusive of any distributing commission or discount. The Fund is adiversified,closed-end management investment company, which commenced investment operations in September 2016.The Fund’s investment objective is current income and overall total return. There is no assurance that the Fund willachieve its investment objectives. The Fund’s Common Shares are listed on the New York Stock Exchange (“NYSE”) under the symbol “OPP.” Asof April 28, 2025, the last reported sale price for the Fund’s Common Shares was $8.23per Common Share. As of thesame date, the last reported NAV for the Fund’s Common Shares was $8.97. Sales of the Fund’s Common Shares, if any, under this Prospectus Supplement and the accompanying Prospectusmay be made in negotiated transactions or transactions that are deemed to be “at the market” as defined in Rule415 underthe Securities Act of 1933, as amended (the “Securities Act”), including sales made directly on the NYSE or sales made toor through a market maker other than on an exchange. The minimum price on any day at which Common Shares may besold will not be less than the then current NAV per Common Share plus the per Common Share amount of the commissionto be paid to the Distributor (the “Minimum Price”). The Fund and the Distributor will determine whether any sales ofCommon Shares will be authorized on a particular day. The Fund and the Distributor, however, will not authorize sales ofCommon Shares if the price per share of the Common Shares is less than the Minimum Price. The Fund and theDistributor may elect not to authorize sales of Common Shares on a particular day even if the price per share of theCommon Shares is equal to or greater than the Minimum Price, or may only authorize a fixed number of Common Sharesto be sold on any particular day. The Fund and the Distributor will have full discretion regarding whether sales ofCommon Shares will be authorized on a particular day and, if so, in what amounts. The Distributor may enter into sub-placement agent agreements with one or more selected dealers. The Distributorhas entered into a sub-placement agent agreement, dated May 20, 2025 (the “Sub-Placement Agent Agreement”), withUBS Securities LLC (the “Sub-Placement Agent”) relating to the Common Shares offered by this Prospectus Supplementand the accompanying Prospectus. In accordance with the terms of the Sub-Placement Agent Agreement, the Fund mayoffer and sell its Common Shares from time to time through the Sub-Placement Agent as sub-placement agent for the offerand sale of its Common Shares. The Fund will compensate the Distributor with respect to sales of Common Shares at acommission rate of 1.00% of the gross proceeds of the sale of Common Shares. Out of this commission, the Distributorwill compensate the Sub-Placement Agent at a rate of up to 0.80% of the gross sales proceeds of the sale of the CommonShares sold by the Sub-Placement Agent. Investing in the Fund’s Common Shares involves certain risks. You could lose some or all of yourinvestment. See “Risks” beginning on page 34 of the accompanying Prospectus. You should consider carefully theserisks together with all of the other information contained in this Prospectus Supplement and the accompanyingProspectus before making a decision to purchase the Fund’s Common Shares. Neither the Securities and Exchange Commission (“SEC”) nor any state securities commission hasapproved or disapproved of these securities or determined if this Prospectus Supplement or the accompanyingProspectus is truthful or complete. Any representation to the contrary is a criminal offense. Prospectus Supplement dated May 20, 2025 (continued on following page) Principal Investment Strategies.The Fund seeks to achieve its investment objective by allocating its ManagedAssets (as defined below) among the three principal investment strategies described below: Tactical Closed-End Fund Income Strategy):This strategy seeks to (i) generate returns through investments inclosed-end funds, special purpose acquisition companies, exchange-traded funds and business development companies(collectively, the “Underlying Funds”) that invest primarily in income-producing securities, and (ii) derive value from thediscount and premium spreads associa



