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If this annual report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section13 or15(d) of the Securities Exchange Act of1934. ☒Yes☐No Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or an emerging growth company. See definition of “large accelerated filer,”“accelerated filer,” and “emerging growth company” in Rule12b-2 of the Exchange Act. If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period forcomplying with any new or revised financial accounting standards† provided pursuant to Section 13(a) of the Exchange Act.☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b)of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report.☒If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error topreviously issued financial statements.☐Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officersduring the relevant recovery period pursuant to §240.10D-1(b).☐Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:☐U.S. GAAP☒International Financial Reporting Standardsas issued by the International Accounting Standards Board☐OtherIf “Other” has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow:Item17☐Item18☐If this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule12b-2 of the Exchange Act).☐Yes☒NoAuditFirmId:1351AuditorName:PricewaterhouseCoopers Auditores Independentes Ltda.AuditorLocation:SãoPaulo,Brasil Certain Terms and ConventionsForward-Looking StatementsPresentation of Financial and Other InformationEffect of RoundingMarket and Industry DataAbout our Financial Information PART IITEM 1.IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISORSITEM 2.OFFER STATISTICS AND EXPECTED TIMETABLEITEM 3.KEY INFORMATION3A.[RESERVED]3B.Capitalization and Indebtedness3C.Reasons for the Offer and Use of Proceeds3D.Risk FactorsITEM 4.INFORMATION ON THE COMPANY4A.History and Development of the Company4B.Business Overview4C.Organizational Structure4D.Property, Plant and EquipmentITEM 4A.UNRESOLVED STAFF COMMENTSITEM 5.OPERATING AND FINANCIAL REVIEW AND PROSPECTS5A.Operating Results5B.Liquidity and Capital Resources5C.Research and Development, Patents and Licenses, Etc.5D.Trend Information5E.Critical Accounting EstimatesITEM 6.DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES6A.Directors and Senior Management6B.Compensation6C.Board Practices6D.Employees6E.Share Ownership6F.Disclosure of a Registrant’s Action to Recover Erroneously Awarded Compensation Table of Contents INTRODUCTION Certain Terms and Conventions All references in this annual report to (i) “Itaú Unibanco Holding,” “Itaú Unibanco Group,” “we,” “us” or “our” are references to Itaú Unibanco Holding S.A. and its consolidated subsidiaries andaffiliates, except where specified or differently required by the context; (ii)the “Brazilian Government” are references to the federal government of the Federative Republic of Brazil("Brazil"); (iii)“preferred shares” arereferences to our authorized and outstanding preferred shares with no par value; and (iv) “common shares” are references to our authorized and outstanding common shareswith no par value. All references to “ADSs” are to American Depositary Shares, each representing one preferred share, without par value.The ADSs are evidenced by American DepositaryReceipts(“ADRs”) issued by JP Morgan Chase Bank("JP Morgan").All references herein to the “real,” “reais” or “R$” are to the Brazilian real, the official currency of Brazil.All references to“US$,” “dollars” or “U.S. dollars” are to United States dollars. Additionally, unless specified or the context indicates otherwise, the following definitions apply throughout this annual report: •“Itaú Unibanco” means Itaú Unibanco S.A., together with its consolidated subsidiaries;•“Itaú BBA” means Banco Itaú BBA S.A., together with its consolidated subsidiaries;•“Central Bank” means the Central Bank of Brazil;•“CLP” means the Chilean peso, the official currency of Chile;•“CMN” means the Brazilian National Monetary Council; and•“CVM” means the Securities and Exchange Commission of Brazil. Addit