Immunome Inc 2024年度报告

FORM 10-K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-39580 Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. YesցNoտ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. YesտNoց Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during thepreceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.YesցNoտ Indicate by check mark whether the registrant has submitted electronically; every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T(§232.0405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).YesցNoտ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growthcompany. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the ExchangeAct. If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financialaccounting standards provided pursuant to Section 13(a) of the Exchange Act.տ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financialreporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. YesտNoց If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect thecorrection of an error to previously issued financial statements.տ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of theregistrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b).տ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). YesտNoց The aggregate market value of the voting common stock held by non-affiliates of the registrant was approximately $642.7 million based on the closing price reported byNASDAQ on June 28, 2024 (the last business day of the registrant’s most recently completed second fiscal quarter). For purposes of making this calculation only, theregistrant has defined affiliates as all executive officers and directors and their affiliates. The number of outstanding shares of the registrant’s common stock as of March 14, 2025 was 86,950,655. Documents Incorporated by Reference Portions of the registrant’s definitive proxy statement on Schedule 14A for the 2025 Annual Meeting of Stockholders to be filed with Securities and Exchange Commissionwithin 120 days after the end of the fiscal year covered by this Form 10-K, are incorporated by reference into Part III, Items 10-14 of this Form 10-K. TABLE OF CONTENTS PART I Item 1. Business6Item 1A. Risk Factors43Item 1B. Unresolved Staff Comments100Item 1C. Cybersecurity100Item 2. Properties101Item 3. Legal Proceedings102Item 4. Mine Safety Disclosures102 PART II103Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of EquitySecurities103Item 6. [Reserved]103Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations104Item 7A. Quantitative and Qualitative Disclosures About Market Risk116Item 8. Financial Statements and Supplementary Data116Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure116Item 9A. Controls and Procedures117Item 9B. Other Information118Item 9C. Disclosure Regarding Foreign Jurisdictions that Prevent Inspections118PART III119Item 10. Directors, Executive Officers and Corporate Governance119Item 11. Executive Compensation119Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters119Item 13. Certain Relationships and Related Transactions, and Director Independence119Item 14. Principal Accountant Fees and Services119PART IV120Item 15. Exhibits and Financial Statement Schedules120Item 16. Form 10-K Summary124Financial Statements1268 9 CAUTIONARY NOTE REGARDING FORWARD-LOOKING