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If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transitionperiod for complying with any new or revised financial accounting standards† provided pursuant to Section 13(a) of the Exchange Act.◻ †The term “new or revised financial accounting standard” refers to any update issued by the Financial Accounting Standards Board to its Accounting Standards Codification after April 5,2012. GRIFOLS, S.A. TABLE OF CONTENTSTABLE OF CONTENTSGENERAL INFORMATIONPRESENTATION OF FINANCIAL AND OTHER INFORMATIONPRESENTATION OF MARKET INFORMATIONPARTIItem1.IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISERSA.Directors and Senior ManagementB.AdvisersC.AuditorsItem2.OFFER STATISTICS AND EXPECTED TIMETABLEA.Offer StatisticsB.Method and Expected TimetableItem3.KEY INFORMATIONA.[Reserved]B.Capitalization and IndebtednessC.Reasons for the Offer and Use of ProceedsD.Risk FactorsItem4.INFORMATION ON THE COMPANYA.History of and Development of the CompanyB.Business OverviewC.Organizational StructureD.Property, Plant and EquipmentE.Regulatory MattersItem4.A.UNRESOLVED STAFF COMMENTSItem5.OPERATING AND FINANCIAL REVIEW AND PROSPECTSA.Operating ResultsB.Liquidity and Capital ResourcesC.Research and Development, Patents and LicensesD.Trend InformationE.Critical Accounting EstimatesItem6.DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEESA.Directors and Senior ManagementB.CompensationC.Board PracticesD.EmployeesE.Share OwnershipF.Disclosure of a Registrant’s Action to Recover Erroneously Awarded Compensation.Item7.MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONSA.Major ShareholdersB.Related Party TransactionsC.Interests of Experts and CounselItem8.FINANCIAL INFORMATIONA.Consolidated Statements and Other Financial InformationB.Significant ChangesItem9.THE OFFER AND LISTINGA.Offer and Listing DetailsB.Plan of DistributionC.Market IIIIIIIIV1111111111111414144767679949494110126126127128128138143149150151152152153157157157159160160160160 D.Selling Shareholders165E.Dilution165F.Expense of the Issue165Item10.ADDITIONAL INFORMATION165A.Share Capital165B.Memorandum and Articles of Association165C.Material Contracts176D.Exchange Controls177E.Taxation178F.Dividends and Paying Agents187G.Statement by Experts187H.Documents on Display187I.Subsidiary Information187J.Annual Report to Security Holders187Item11.QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK188Item12.DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES189A.Debt Securities189B.Warrants and Rights189C.Other Securities189D.American Depositary Shares189GLOSSARY OF TERMS191PARTII197Item13.DEFAULTS, DIVIDEND ARREARAGES AND DELINQUENCIES197Item14.MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY HOLDERS AND USE OFPROCEEDS197Item15.CONTROLS AND PROCEDURES197A.Evaluation of Disclosure Controls and Procedures197B.Management’s Report on Internal Control over Financial Reporting198C.Attestation Report of the Registered Public Accounting Firm199D.Changes in Internal Control over Financial Reporting199Item16.[RESERVED]200Item16.AAUDIT COMMITTEE FINANCIAL EXPERT200Item16.B CODE OF ETHICS200Item16.CPRINCIPAL ACCOUNTANT FEES AND SERVICES200Item16.DEXEMPTION FROM THE LISTING STANDARDS FOR AUDIT COMMITTEES201Item16.E PURCHASES OF EQUITY SECURITIES BY THE ISSUER AND AFFILIATED PURCHASERS201Item16.F CHANGES IN REGISTRANT’S CERTIFYING ACCOUNTANT201Item16.GCORPORATE GOVERNANCE201Item16.HMINE SAFETY DISCLOSURE204Item16.I DISCLOSURE REGARDING FOREIGN JURISDICTIONS THAT PREVENT INSPECTIONS204Item 16.JINSIDER TRADING POLICIES204Item 16.KCYBERSECURITY205PARTIII208Item17.FINANCIAL STATEMENTS208Item18.FINANCIAL STATEMENTS208Item19.EXHIBITS208SIGNATURES212 GENERAL INFORMATION As used in this annual report on Form20-F, unless the context otherwise requires or as is otherwiseindicated: ●all references to “Grifols,” the “Company,” “we,” “us” and “our” refer to Grifols, S.A., acompany (sociedad anónima) organized under the laws of Spain, and our consolidatedsubsidiaries;●all references to the “Group” or the “Grifols Group” are to Grifols, S.A. and the group ofcompanies owned or controlled by Grifols, S.A; and●see “Glossary of Terms” for further explanations and/or definitions of terms referenced in thisForm20-F. PRESENTATION OF FINANCIAL AND OTHER INFORMATION The basis of presentation of financial information of Grifols in this document is in conformity withInternational Financial Reporting Standards, or IFRS, as issued by the International Accounting Standards Board,or IASB (jointly, “IFRS-IASB”) and other legislative provisions containing the applicable legislation governingour financial information, unless indicated otherwise. All references in this annual report on Form20-F to (i)“euro,” “€” or “EUR” are to the commoncurrency of the European Union and (ii)“U.S. dollar,” “$” or “USD” are to the currency of the United States. The functional and presentation currency of Grifols is the