四环医药：截至二零二四年十二月三十一日止年度的全年业绩公告

SihuanPharmaceutical Holdings Group Ltd.0460 •1,901.11,860.52.2%40.6•744.2449.965.4%294.3 •1,099.31,398.821.4%299.5 •57.611.8388.1%45.8 •659.4564.994.516.7% •1,241.71,295.64.2%53.9 •473.9577.718.0%103.8 •138.1161.7418.089.1328.9 •471.5257.783.0%213.8•216.754.0301.3%162.7•2.34•243.93,976.4 NASH1060+40+ +Sylfirm X®SGLT-2GLP-1DPP-4ALK+SGLT-2+ •7Sylfirm X •®®New Drug ApplicationNDA1SGLT-2®+ •Investigational New DrugINDIIIGLP-1 •ALK1XZP-3621(ALK)(NSCLC) •1,5006,20070771,18340070%4034®®Sylfirm X® •+40302,300801,000 •®CellontechCartiZol •GLP-1SGLT-2® •SGLT-220242024 • + • • • •Genesis Biosystems, Inc.Genesis • ••• 3.0744.265.4%251.0173.4% +BD607Sylfirm X2IIICellontechCartiZolIII58HA 70%+®Sylfirm X403470771,200400®1,5006,200®®Sylfirm X® Sylfirm X(VIOL.Co., Ltd.)Sylfirm X(FDA) Sylfirm XSylfirm XKeyOpinion LeaderKOLSylfirm XKOL ®®32B23900young clubyoung clubyoung club3200 83508,0003,000KOL4KOL25 GenesisGenesisDermaGenesis®Dermacel®DermaFrac™Lipivage®GenesisGenesis ®®Sylfirm X® 57.6388.1%948.0 1.9 914®®®IIIINDIII 92Abbreviated New Drug ApplicationANDA10 ®®III®®25428 70%30% ®SGLT-21SGLT-21IIISGLT-2 IIIINDIIIGLP-1GLP-127938.4%20025.4%80.585.7%58 12,000LGMPFDA 30503ADPP-4 +4030302,300 FDA 2. 10(ADC)124New Drug ApplicationNDA4I4IND 10+NASH1 124NDA4I4IND XZP-3287GMPNDAHR+HER2-CDK4/6CDK4/6240HR+HER2-75%CDK4/6HR+HER2-CDK4/610022CDK4/6130 1XZP-3621 NDA(CDE)(ALK)(NSCLC)IIIALKALKNSCLCXZP-3621Objective Response RateORRALKIIIORRALKXZP-3621ALKNSCLC4287ALKNSCLCINDALKNSCLC15,80026,2005.8% 1XZP-6924INDXZP-69241(USP1)(First in class) USP1PARPDNA(DDR)DDRPARPUSP1DNAPARPBRCA1/2XZP-6924USP1USP1USP1BRCAUSP1398,200 1XZP-7797INDINDXZP-7797ADP1(PARP1)PARP1/2(BRCA)PARP1/2BRCAPARP1PARP2XZP-7797PARP1PARP220%BRCA144.7%PARPXZP-7797PARP ®®801,000 1XZP-58495(PDE5) H 29,791,1628% + 1,099.321.4%356.536.8% 10030(2.5mg)1011A 20100% 5 4 6 (2.34)(0.58) 4,949,3045,137,024 1 161177 (a)1616 (b) (c)77 15 2. (a)(b)(c) 10% 3. 1,901,109 (24,991) 1,860,539 (b) 90180 (i) (ii) 2,83013,170–44,190 2,83057,360 8,4432,830 (iii)30 (i) 4. (i) (ii) (iii) 5. 1614 276,446271,254(1,515)(1,917) 274,931269,337 6. (428,288)(161,260)(100,742)(35,323)(18,357)(3,055)(19,396)(46,332)(74,874)(125,829)111,10213,846(7,537)(7,644)5078,092(20,391)(33,474)236,949326,1465%(64,000)–43,26196,427 12% 21.0% 16.5%16.5% 25% 15% 7. 177,080,000298,560,000 –298,560177,080–177,080298,560 3.21.9) 8. 216,662,00054,017,0009,265,984,0009,297,073,000 * ** (2.34)(0.58) 12 647,591649,619 11. 170,451354,275 (ii)110,578589,016 110,578589,016 281,029943,291 (i) (ii) (ii) 35,697,000 7,000 (iii) (iv) 926,721,00028,311,000 (i)9,899,0009,001,00017,500,000 (ii)12,367,00011,297,00020,000,000 85,933,00048,433,000 14. (i)8,686,00011,264,000 (ii)32,254,0008,289,00039,889,0001,000,0001,000,00032,254,000 15 (iii)42,361,0002,683,00012,115,000 (iv)1,265,193,000 241,933215,150 (a) 17. (b) 1,901.11,860.52.2%40.6 744.2449.965.4%294.3 1,099.31,398.821.4%299.5 57.611.8388.1%45.8 659.4564.994.516.7% 1,241.71,295.64.2%53.9 65.3%69.6%4.3%57.8% 123.7216.142.8%92.4 430.1442.32.8%12.2 745.4469.058.9%276.4 473.9577.718.0%103.8 102.259.073.2%43.2 138.1161.7418.089.1328.9 274.9269.32.1%5.6228.8211.3 428.3161.3165.5%267.0 43.396.455.1%53.1 471.5257.783.0%213.8 216.754.0301.3%162.7 254.9203.725.1%51.2 3,976.44,610.513.8%634.1785.33,522.43,778.7110.6589.0343.4242.8243.9 8,763.614.2214.2314.075% 841.81,133.841.540.991.0%9.0%75%25%20.2%26.5% 417.0557.325.2%140.3266371 1,424.21,134.825.5%289.4593.9397.849.3%196.1 2,007.52,174.67.7%167.1 841.7776.08.5%65.7 1,687.91,710.81.3%22.9 181.8 186.470.7115.7 16 2,667912.5681.135.8418.047.689.1 25% 12.3220,000,0001 20,000,000 C1 C3 1617 (www.sihuanpharm.com)(www.hkexnews.hk) 1617sihuanpharm-ecom@vistra.com