HOOKIPA Pharma Inc 2024年度报告

FORM 10-K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-38869 HOOKIPA PHARMA INC.(Exact name of registrant as specified in its charter) Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities ExchangeAct of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has beensubject to such filing requirements for the past 90 days. YesNo Indicate by check mark whether the Registrant has submitted electronically; every Interactive Data File required to be submitted pursuant toRule 405 of Regulation S-T (§232.0405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant wasrequired to submit such files). YesNo Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reportingcompany, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and“emerging growth company” in Rule 12b-2 of the Exchange Act. Large accelerated filerAccelerated filerNon-accelerated filerSmaller reporting companyEmerging growth company If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complyingwith any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of itsinternal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accountingfirm that prepared or issued its audit report. If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrantincluded in the filing reflect the correction of an error to previously issued financial statements. Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-basedcompensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b). Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). YesNo Based on the closing price as reported on the Nasdaq Global Select Market, the aggregate market value of the Registrant's Common Stockheld by non-affiliates on June 30, 2024 (the last business day of the Registrant's most recently completed second fiscal quarter) wasapproximately $57.0 million. Shares of Common Stock held by each executive officer and director and by each shareholder affiliated with adirector or an executive officer have been excluded from this calculation because such persons may be deemed to be affiliates. This determinationof affiliate status is not necessarily a conclusive determination for other purposes. The number of outstanding shares of the Registrant's CommonStock as of February 24, 2025 was 9,659,522 shares and 2,399,517 shares of Class A common stock outstanding, each $0.0001 par value pershare. Documents Incorporated by Reference If the Registrant’s Definitive Proxy Statement relating to the 2025 Annual General Meeting of Shareholders (the “Proxy Statement”) is filed withthe Commission within 120 days after the end of the fiscal year covered by this Annual Report on Form 10-K, then portions of the ProxyStatement will be incorporated by reference into Part III of this Annual Report on Form 10-K. If the Proxy Statement is not filed within such 120-day period, then the Registrant will file an amendment to this Annual Report within such 120-day period that will contain the informationrequired to be included or incorporated by reference into Part III of this Annual Report. Table of Contents PART IItem 1.Business6Item 1A. Risk Factors56Item 1B. Unresolved Staff Comments113Item 1C. Cybersecurity113Item 2.Properties114PART IIItem 3.Legal Proceedings115Item 4.Mine Safety Disclosures115Item 5.Market for Registrant's Common Equity, Related Stockholder Matters and Issuer Purchases ofEquity Securities115Item 6.[Reserved]116Item 7.Management’s Discussion and Analysis of Financial Condition and Results of Operations116Item 7A. Quantitative and Qualitative Disclosures About Market Risk136Item 8.Financial Statements and Supplementary Data137Item 9.Changes in and Disagreements with Accountants on Accounting and Financial Disclosure137Item 9A. Controls and Procedures137Item 9B. Other Information138Item 9C. Disclosure regarding Foreign Jurisdictions that Prevent In