核酸四面体蓝皮书

tetrahedralframeworknucleicacids tFNA tFNADNARNADNADNADNADNAtFNA tFNAtFNAtFNA tFNAtFNAtFNAtFNAtFNAtFNAtFNA tFNAtFNA tFNAtFNAtFNAtFNA ◼ 12 —— DNA —— tFNAs,asapromisingnanomaterial,demonstratesignificantpotentialinbothwellnessandbeautyindustry.Butthistechnologyalsohasquiteafewconstraintstoovercome,e.g.,production,safety,regulatory,etc.ShiseidoCICappreciateTrautecembracethischallenge.AndsincerelycongratulateTrautecontFNAs R&DprogressandBluePaperpublished!Asatopbeautyandwellnessglobalgroup,wearealsolookingforwardtoresearchdeepeningandtechnologyadvancementontFNAs,especiallyefficacyandsafety.Incomingfuture,tFNAswillplayamoreandmoreimportantroleonbiomedicineandpersonalcare,evenfromglobalwise,withjointeffortsfromdifferentindustries. ——Shiseido China CIO ArakiHidefumi XVII —— ◼ AllergantFNAstFNAstFNAs —Tony Wang —— tFNAisananohigh-techmaterialhighlyanticipatedforuseasaplatformtechnologythatcanenhanceefficacynotonlyinbiomedicineanddiseasediagnosisbutalsoincosmetics,whichareclosetoourdailylives.TrauTECdeservescreditforachievingthecommercialproductionoftFNA,whichischallengingtosynthesize.WeappreciateTrauTEC'seffortsinpioneeringanunchartedpathforitsfirstapplicationinthecosmeticsfield,leadingsafetyandefficacytests,andsharingtheprocessandresultswiththeindustrythroughthepublicationofthebluebook.WehopethatCosmax,theworld’sleadingOBM/ODMcompany,propagatesvarioushigh-efficacymaterialsdevelopedbasedontFNAintocosmetics,andthatwecollaboratetocreatebeautyworldwide. ——COSMAX China R&I/ BCT Director KimYoungheui In2023,wefinallygotbigcriteriaofaging12hallmarks.Thechangewillmakethegameofsailingforfuturehealthcareandbeautycareinthepointofaging.Last25yearswegottechnologyofpeptidesandmadeinnovationofhealthcareandespeciallyofbeautycare.AndpandemicexperiencerealizedNucleotidestechnologyforhealthcare.Trautec,here,startsnextinnovativetechnologyofnucleotides,calledtFNAs.Thischallengewillopentheworldfornext25yearshealthcare,beautycarerevolution.tFNAshasmultifunction,suchasdrugdelivery,injectivetissueremodelingandalsotopicalanti-agingpropertybyitself.Thishighpotentialbio-materialwillbeakeytechnologyforcominghyper-personalizedhealthcarewithAIandwearablemonitoringsystem.HereSincerelycongratulateTrautecnewinnovationandexpectcontinuouschallengetorealizetFNAtechnologiesinvariouslifescene. ——NaturelabJapan R&D senior manager AtsushiTakeoka ◼ 1.1--------------------------------101.2--------------------------------111.3--------------------------------121.4--------------------------------131.4.1DNA--------------------------------131.4.2RNA--------------------------------141.4.3--------------------------------161.5--------------------------------201.6--------------------------------21 DNA --------------------------------23--------------------------------23--------------------------------23--------------------------------25--------------------------------27--------------------------------29--------------------------------31--------------------------------34--------------------------------34--------------------------------34--------------------------------35--------------------------------36--------------------------------38 ◼ 3.1--------------------------------413.2--------------------------------423.2.1--------------------------------433.2.2--------------------------------443.2.3--------------------------------463.2.4--------------------------------473.2.5--------------------------------49 --------------------------------53--------------------------------54--------------------------------55--------------------------------55--------------------------------57--------------------------------59--------------------------------60--------------------------------63--------------------------------63--------------------------------65--------------------------------66--------------------------------70--------------------------------70--------------------------------72--------------------------------73 4.1tFNA4.2tFNA4.34.3.14.3.24.3.34.3.4 4.4.14.4.24.4.3 4.54.5.14.5.24.5.3 ◼ --------------------------------75--------------------------------75--------------------------------75--------------------------------75--------------------------------77--------------------------------77--------------------------------78--------------------------------79--------------------------------81 4.6 4.6.14.6.24.6.3 4.7.14.7.2PNA4.7.3AMP4.7.4ASO 5.15.25.35.45.55.6 --------------------------------84--------------------------------86--------------------------------87--------------------------------88--------------------------------89--------------------------------90 6.1tFNA--------------------------------926.2tFNA--------------------------------946.2.1--------------------------------946.2.2--------------------------------946.2.3--------------------------------956.2.4--------------------------------95 ◼ 6.2.5--------------------------------96 6.4 ◆◆◆ --------------------------------105 --------------------------------114 ------------------