德琪医药-B2023 年度报告

(於開曼群島註冊成立的有限公司)股票代號: 6996 2 46101327325977121126127128129130132 John F. Chin 20234 14 Maples Corporate Services LimitedPO Box 309, Ugland HouseGrand Cayman, KY1-1104Cayman Islands Rafael Fonseca20234 14Mark J. Alles20234 14 1065SOHOB1206-1209 Rafael Fonseca 110 Rafael Fonseca 881739901 2023414 Rafael Fonseca 97927 Maples Fund Services (Cayman) LimitedP.O. Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands 183171712-1716 6996 www.antengene.comwww.antengene.cn Davis Polk & Wardwell3A10 20201120 2024614 717710 161 3 *** ** 20221231160.192.82023123167.3(i)20238®(ii)202312®(iii)202383692.HK® 20221231293.9178.120231231115.8 20221231488.582.820231231405.7 20221231355.4162.720231231192.7® 20221231167.119.020231231148.1 20221231601.520.320231231581.2 20221231550.216.320231231533.9 20221231805.4224.920231231580.527.9%®2023® 20231231 •ATG-010XPOVIO®®XPO1 •20238®®®200100100535® •202312®20232023(PI)(IMiD)CD38(mAb)(rrMM)2023202411 •20235(BPOM)®(NDA)B(rrDLBCL) •20236®(XVd)(PBS) •20237®NDA(Xd)PIsIMiDsCD38 mAb 202312®NDA(Xd)PIsIMiDsCD38 mAb OnatasertibATG-008 mTORC1/2 •20235I/IITORCH-22023(ASCO 2023) EltanexorATG-016XPO1 •ATG-016II ATG-017ERK1/2 •20237ATG-017ERASERI ATG-101PD-L1/4-1BB •ATG-101PD-L1/4-1BBB(B-NHL)IPROBE-CNPROBE PROBEI(PR)(MSS)3 ATG-037CD73 •20237ATG-037IPD-1STAMINA STAMINAI3PRCPI321CPIPD-1 ATG-018ATR •ATG-018IATRIUM ATG-022Claudin 18.2 •20233ATG-022CLINCHI(IND) 20233CLINCH 20235ATG-022(FDA)(ODDs) 20235CLINCH CLINCHI7Claudin 18.22(CR)PR ATG-031CD24 •20235FDAINDATG-031B-NHLIPERFORM 202312B-NHLPERFORM •ATG-042PRMT5-MTAATG-102LILRB4 x CD3 T •2+1TAnTenGagerTMT(CRS) 20231Calithera Biosciences, Inc.CalitheraATG-03720215CalitheraATG-037CalitheraCalitheraATG-037 •20238®®®200100100535® 20231231 20232023 MD(MDAnderson Cancer Center) ATG-031CD24ATG-031CD24 ATG-022Claudin 18.2ADCClaudin 18.2ATG-022Claudin 18.2 ATG-037CD73PD-1ATG-037CD73(ICI)ICI ATG-101PD-L1/4-1BBATG-101PD-L14-1BB(MSS) ATG-008mTORC1/2ATG-008mTORC1mTORC2(ICI)(ORR)53.3%ICI23.1%80% 2024 T(TCE)AnTenGager™TCE 2023®®®®® 2024(ESG)11.88 2024 2017 2024322 2017 9137®NDABPOM®NDAB 2023®NDAB2023NDA ATG-010XPOVIO®®XPO1 ®(SINE)Karyopharm Therapeutics Inc.Karyopharm® Karyopharm201973FDA®PIsIMiDsCD38 mAb 2020622®FDABB20201218FDA® 20217MFDS®PIsIMiDsCD38 mAbNDAB202112MFDS(sNDA® 202112®PIIMiDCD38 mAb 20235BPOM®NDAB 20236®(XVd)PBS 20237®NDA(Xd)PIsIMiDsCD38 mAb 20238®®®200100100535® 202312®NDA(Xd)PIsIMiDsCD38 mAb 202312®2023PIIMiDCD38 mAb2023202411 ®NDA®(Xd)(XVd)PBSBPOM®NDA ® BI ISEARCH IIIBENCH R-GDPBII/IIIKaryopharm(XPORT-DLBCL-030) ATG-008onatasertib mTORC1/2 ATG-008 (onatasertib)Celgene Corporationonatasertib2020HCC3202144TORCHonatasertibPD-1I/IITORCH-2 20235I/IITORCH-22023(ASCO 2023) ATG-008 (ONATASERTIB) EltanexorATG-016XPO1Karyopharmeltanexor2020MDSI/IIIND2021520215I/IIIND20223ATG-016(MDS)IIINDI/IIeltanexor (ATG-016)HMAIPSS-RMDSHATCH ATG-017ERK1/2AstraZeneca ABAstraZenecaATG-0172020IATG-017PD-1ERASER202112ATG-017PD-1Opdivo®202210FDAERASER20237ATG-017I ATG-101PD-L1/4-1BB20223ATG-101IIND2022820229ATG-101FDAODD ATG-037CD7320222HRECI20226202211ATG-037 I20237202212STAMINA-001ATG-037PD-1®I ATG-018ATR20226HRECATG-018 I20228 ATG-022Claudin 18.2202212HRECATG-022 I2023320233IND2023520235ATG-022FDAODD ATG-031CD2420235FDAINDB-NHLPERFORMI202312 ATG-042PRMT5-MTAATG-042IND/CTA ATG-102LILRB4 x CD3 TATG-102IND/CTA AnTenGagerTM TAnTenGagerT 20231231149ATG-010XPO1ATG-008onatasertibmTORC1/2ATG-016eltanexorXPO1ATG – 017ERK1/2ATG-101PD-L1/4-1BBATG-037CD73ATG-018ATRATG-022Claudin 18.2ATG-031CD2420231231®NDA2023712®NDA®BPOMNDA®(Xd)(XVd)PBS 2023123120221231374.6461.420231231(PCT)5PCT2 20231CalitheraATG-03720215CalitheraATG-037CalitheraCalitheraATG-037 20238®®®2115.35® 20243ATG-042ATG-102 ATG-022TAnTenGagerTM20244520244102024 2021®ATG-010NDA20222023 NDA® 2024III 20231231 20221231160.192.82023123167.3(i)20238®(ii)202312®202411(iii)20238®2023® 20221231293.9178.120231231115.82023123146.620221231255.3 20221231488.582.820231231405.7(i)CROCDMOSMO123.9(ii)29.02023123142.2CalitheraATG-0372022123113.2 20221231355.4162.720231231192.7(i)®79.1(ii)63.2(iii)11.420232024 20221231167.119.020231231148.1 20231231 2023123116635 202312311,187.7202212311,789.620231231100.05.620221231135.8 20231231 202312311,241.81,187.754.120231231190.9179.811.1 100%20231231650.6%20221231496.6% 100%2023123129.1%2022123120.0% 2023123120231231 20231231 20231231 2023123143.4 5920188282020818 3070 2001820012Johnson & Johnson Pharmaceutical Research &Development, L.L.C.20064200810Novartis AGNOVN.SIXNVS.NYSENovartis Oncology20081020173CelgeneBMY.NYSE®POMALYST®IDHIFA®201411202012201742022224SanReno Therapeutics Holding Limited 19897199412006 John F. Chin582020122020818Chin Chin1990Merck, Sharp and Dohme CorpBMY. NYSE1992119987199810Aventis Pharmaceutical Holdings Inc.1999Rhône-Poulenc Rorer2005120201ChinCelgeneBMY.NYSE Chin19891219984 422020682021618 16200462008112012